TY - JOUR
T1 - Autoimmune T cell recognition of human acetylcholine receptor
T2 - the sites of T cell recognition in myasthenia gravis on the extracellular part of the α subunit
AU - Oshima, Minako
AU - Ashizawa, Tetsuo
AU - Pollack, Marilyn S.
AU - Atassi, M. Zouhair
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1990/12
Y1 - 1990/12
N2 - Autoimune T cell lines were prepared from peripheral blood lymphocytes of five myasthenia gravis patients by passage in vitro with an equimolar mixture of 18 overlapping synthetic peptides corresponding to the entire extracellular region (residues α1‐210) of the α subunit of human acetylcholine receptor (AChR). The proliferative responses of the human AChR‐specific T cell lines to each of the individual peptides were determined. It was found that the profiles of the peptides recognized by the T cells were different among the five T cell lines, consistent with genetic control operating at the recognition site level. However, other regulatory influences may play important roles in the triggering of the autoimmune responses. These results suggest that the pathogenesis of this autoimmune disease is variable at the cellular‐molecular level.
AB - Autoimune T cell lines were prepared from peripheral blood lymphocytes of five myasthenia gravis patients by passage in vitro with an equimolar mixture of 18 overlapping synthetic peptides corresponding to the entire extracellular region (residues α1‐210) of the α subunit of human acetylcholine receptor (AChR). The proliferative responses of the human AChR‐specific T cell lines to each of the individual peptides were determined. It was found that the profiles of the peptides recognized by the T cells were different among the five T cell lines, consistent with genetic control operating at the recognition site level. However, other regulatory influences may play important roles in the triggering of the autoimmune responses. These results suggest that the pathogenesis of this autoimmune disease is variable at the cellular‐molecular level.
UR - http://www.scopus.com/inward/record.url?scp=0025639188&partnerID=8YFLogxK
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U2 - 10.1002/eji.1830201206
DO - 10.1002/eji.1830201206
M3 - Article
C2 - 2269324
AN - SCOPUS:0025639188
VL - 20
SP - 2563
EP - 2569
JO - European Journal of Immunology
JF - European Journal of Immunology
SN - 0014-2980
IS - 12
ER -