Autoimmune-related retinopathy and optic neuropathy accompanied by anti-GAD antibodies

Sumayya J. Almarzouqi; Michael L. Morgan; Petros E. Carvounis; Andrew G. Lee

doi:10.3109/01658107.2015.1050744

Autoimmune-related retinopathy and optic neuropathy accompanied by anti-GAD antibodies

Sumayya J. Almarzouqi, Michael L. Morgan, Petros E. Carvounis, Andrew G. Lee

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Autoimmune-related retinopathy and optic neuropathy is characterized by visual loss in the presence of antibodies against retina or optic nerve antigens in the absence of neoplasia. We report a case with progressive central visual loss accompanied by latent autoimmune diabetes in an adult. Visual fields, multimodal imaging and electrophysiological testing showed characteristic changes without evidence of neoplasia on positron emission tomography. Immunologic testing revealed abnormal reactivity against a 20 kDa optic nerve antigen and 40 kDa and 62 kDa retina antigens along with antibodies against anti-glutamic acid decarboxylase, a constellation which we believe to be unique.

Original language	English (US)
Pages (from-to)	195-200
Number of pages	6
Journal	Neuro-Ophthalmology
Volume	39
Issue number	4
DOIs	https://doi.org/10.3109/01658107.2015.1050744
State	Published - 2015

Keywords

ARRON
Anti-GAD
Autoimmune optic neuropathy
Autoimmune retinopathy
Optic nerve autoantibody
Retinal autoantibody

ASJC Scopus subject areas

Ophthalmology
Clinical Neurology

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title = "Autoimmune-related retinopathy and optic neuropathy accompanied by anti-GAD antibodies",

abstract = "Autoimmune-related retinopathy and optic neuropathy is characterized by visual loss in the presence of antibodies against retina or optic nerve antigens in the absence of neoplasia. We report a case with progressive central visual loss accompanied by latent autoimmune diabetes in an adult. Visual fields, multimodal imaging and electrophysiological testing showed characteristic changes without evidence of neoplasia on positron emission tomography. Immunologic testing revealed abnormal reactivity against a 20 kDa optic nerve antigen and 40 kDa and 62 kDa retina antigens along with antibodies against anti-glutamic acid decarboxylase, a constellation which we believe to be unique.",

keywords = "ARRON, Anti-GAD, Autoimmune optic neuropathy, Autoimmune retinopathy, Optic nerve autoantibody, Retinal autoantibody",

author = "Almarzouqi, {Sumayya J.} and Morgan, {Michael L.} and Carvounis, {Petros E.} and Lee, {Andrew G.}",

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AU - Almarzouqi, Sumayya J.

AU - Morgan, Michael L.

AU - Carvounis, Petros E.

AU - Lee, Andrew G.

PY - 2015

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N2 - Autoimmune-related retinopathy and optic neuropathy is characterized by visual loss in the presence of antibodies against retina or optic nerve antigens in the absence of neoplasia. We report a case with progressive central visual loss accompanied by latent autoimmune diabetes in an adult. Visual fields, multimodal imaging and electrophysiological testing showed characteristic changes without evidence of neoplasia on positron emission tomography. Immunologic testing revealed abnormal reactivity against a 20 kDa optic nerve antigen and 40 kDa and 62 kDa retina antigens along with antibodies against anti-glutamic acid decarboxylase, a constellation which we believe to be unique.

AB - Autoimmune-related retinopathy and optic neuropathy is characterized by visual loss in the presence of antibodies against retina or optic nerve antigens in the absence of neoplasia. We report a case with progressive central visual loss accompanied by latent autoimmune diabetes in an adult. Visual fields, multimodal imaging and electrophysiological testing showed characteristic changes without evidence of neoplasia on positron emission tomography. Immunologic testing revealed abnormal reactivity against a 20 kDa optic nerve antigen and 40 kDa and 62 kDa retina antigens along with antibodies against anti-glutamic acid decarboxylase, a constellation which we believe to be unique.

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KW - Autoimmune optic neuropathy

KW - Autoimmune retinopathy

KW - Optic nerve autoantibody

KW - Retinal autoantibody

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Autoimmune-related retinopathy and optic neuropathy accompanied by anti-GAD antibodies

Abstract

Keywords

ASJC Scopus subject areas

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