Autoimmune-related retinopathy and optic neuropathy accompanied by anti-GAD antibodies

Sumayya J. Almarzouqi, Michael L. Morgan, Petros E. Carvounis, Andrew G. Lee

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Autoimmune-related retinopathy and optic neuropathy is characterized by visual loss in the presence of antibodies against retina or optic nerve antigens in the absence of neoplasia. We report a case with progressive central visual loss accompanied by latent autoimmune diabetes in an adult. Visual fields, multimodal imaging and electrophysiological testing showed characteristic changes without evidence of neoplasia on positron emission tomography. Immunologic testing revealed abnormal reactivity against a 20 kDa optic nerve antigen and 40 kDa and 62 kDa retina antigens along with antibodies against anti-glutamic acid decarboxylase, a constellation which we believe to be unique.

Original languageEnglish (US)
Pages (from-to)195-200
Number of pages6
JournalNeuro-Ophthalmology
Volume39
Issue number4
DOIs
StatePublished - 2015

Keywords

  • ARRON
  • Anti-GAD
  • Autoimmune optic neuropathy
  • Autoimmune retinopathy
  • Optic nerve autoantibody
  • Retinal autoantibody

ASJC Scopus subject areas

  • Ophthalmology
  • Clinical Neurology

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