TY - JOUR
T1 - Autoimmune liver disease and the enteric microbiome
AU - Glassner, Kerri
AU - Quigley, Eamonn M.M.
AU - Franco, Lissa
AU - Victor, David W.
N1 - Publisher Copyright:
© 2018 the Author(s), licensee AIMS Press.
PY - 2018
Y1 - 2018
N2 - The human enteric microbiome is highly complex and has more than 150 times more genes within it than its host. The host and the microbiome have a commensurate relationship that can evolve over time. The typically symbiotic relationship between the two can become pathogenic. The microbiome composition in adults reflects their history of exposure to bacteria and environmental factors during early life, their genetic background, age, interactions with the immune system, geographical location, and, most especially, their diet. Similarly, these factors are thought to contribute to the development of autoimmune disease. It is possible that alterations in the intestinal microbiome could lead to liver disease. There is emerging data for the contribution of the microbiome in development of primary sclerosing cholangitis, primary biliary cholangitis, and autoimmune hepatitis; liver disorders associated with aberrant immune function in genetically susceptible individuals.
AB - The human enteric microbiome is highly complex and has more than 150 times more genes within it than its host. The host and the microbiome have a commensurate relationship that can evolve over time. The typically symbiotic relationship between the two can become pathogenic. The microbiome composition in adults reflects their history of exposure to bacteria and environmental factors during early life, their genetic background, age, interactions with the immune system, geographical location, and, most especially, their diet. Similarly, these factors are thought to contribute to the development of autoimmune disease. It is possible that alterations in the intestinal microbiome could lead to liver disease. There is emerging data for the contribution of the microbiome in development of primary sclerosing cholangitis, primary biliary cholangitis, and autoimmune hepatitis; liver disorders associated with aberrant immune function in genetically susceptible individuals.
KW - Autoimmune hepatitis
KW - Microbiome
KW - PBC
KW - PSC
KW - Primary biliary cholangitis
KW - Primary sclerosing cholangitis
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U2 - 10.3934/MICROBIOL.2018.2.334
DO - 10.3934/MICROBIOL.2018.2.334
M3 - Review article
AN - SCOPUS:85114117795
SN - 2471-1888
VL - 4
SP - 334
EP - 346
JO - AIMS Microbiology
JF - AIMS Microbiology
IS - 2
ER -