Autoantibodies as potential biomarkers in breast cancer

Jingyi Qiu, Bailey Keyser, Zuan Tao Lin, Tianfu Wu

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Breast cancer is a major cause of mortality in women; however, technologies for early stage screening and diagnosis (e.g., mammography and other imaging technologies) are not optimal for the accurate detection of cancer. This creates demand for a more effective diagnostic means to replace or be complementary to existing technologies for early discovery of breast cancer. Cancer neoantigens could reflect tumorigenesis, but they are hardly detectable at the early stage. Autoantibodies, however, are biologically amplified and hence may be measurable early on, making them promising biomarkers to discriminate breast cancer from healthy tissue accurately. In this review, we summarized the recent findings of breast cancer specific antigens and autoantibodies, which may be useful in early detection, disease stratification, and monitoring of treatment responses of breast cancer.

Original languageEnglish (US)
Article number67
JournalBiosensors
Volume8
Issue number3
DOIs
StatePublished - Jul 13 2018

Keywords

  • Autoantibody
  • Breast cancer
  • Early diagnosis
  • Immunotherapy

ASJC Scopus subject areas

  • Clinical Biochemistry

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