Augmentation of targeted delivery with pulsed high intensity focused ultrasound

Brian O'Neill, King C.P. Li

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations


This paper reviews the enhanced delivery of genes, drugs and therapeutics using ultrasound. It begins with a general overview of the field and the various techniques associated with it, including sonophoresis, hyperthermia (with ultrasound), sonoporation, and microbubble assisted transvascular and targeted delivery. Particular attention is then paid to pulsed high intensity focused ultrasound drug delivery without the use of ultrasound contrast agents. Feasibility and mechanistic studies of this technique are described in some detail. Conclusions are then drawn regarding possible mechanisms of this treatment, and to contrast with the better known treatments relying on injection of ultrasound contrast agents.

Original languageEnglish (US)
Pages (from-to)506-520
Number of pages15
JournalInternational Journal of Hyperthermia
Issue number6
StatePublished - Jan 1 2008


  • Gene therapy
  • High intensity focused ultrasound
  • Targeted drug delivery

ASJC Scopus subject areas

  • Cancer Research
  • Physiology
  • Radiological and Ultrasound Technology
  • Physiology (medical)


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