Atypical corneal immunoglobulin deposition in a patient with dysproteinemia

Alice Y. Matoba, Patricia Chevez-Barrios, Dan B. Jones

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Purpose: The purpose of this study was to report an unusual pattern of immunoglobulin deposition in the corneas of a patient with dysproteinemia. Methods: Clinical examination, slit lamp examination, a deep lamellar corneal biopsy, and serum and aqueous protein electrophoresis were obtained. Results: Slit lamp evaluation revealed amorphous, cloud-like opacities in the midperiphery at the level of deep stroma and Descemet's membrane. Electron microscopy demonstrated deep lamellar extracellular deposits consistent with immunoglobin. The serum protein electrophoresis revealed a monoclonal IgG kappa band, but the aqueous electrophoresis showed no bands in the gamma region. Conclusion: This case documents a rare pattern of immunoglobulin deposition in the corneas in a patient with gammopathy. Despite its deep corneal distribution, the analysis of the aqueous specimen suggests that the source of the immunoglobulin is through a route other than from the aqueous.

Original languageEnglish (US)
Pages (from-to)105-107
Number of pages3
JournalCornea
Volume29
Issue number1
DOIs
StatePublished - Jan 2010

Keywords

  • Corneal deposit
  • Corneal opacity
  • Dysproteinemia

ASJC Scopus subject areas

  • Ophthalmology

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