Atrial Fibrillation and Longitudinal Change in Cognitive Function in CKD

CRIC Study Investigators

doi:10.1016/j.ekir.2020.12.023

Atrial Fibrillation and Longitudinal Change in Cognitive Function in CKD

CRIC Study Investigators

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Background: Studies in the general population suggest that atrial fibrillation (AF) is an independent risk factor for decline in cognitive function, but this relationship has not been examined in adults with chronic kidney disease (CKD). We investigated the association between incident AF and changes in cognitive function over time in this population. Methods and Results: We studied a subgroup of 3254 adults participating in the Chronic Renal Insufficiency Cohort Study. Incident AF was ascertained by 12-lead electrocardiogram (ECG) obtained at a study visit and/or identification of a hospitalization with AF during follow-up. Cognitive function was assessed biennially using the Modified Mini-Mental State Exam. Linear mixed effects regression was used to evaluate the association between incident AF and longitudinal change in cognitive function. Compared with individuals without incident AF (n = 3158), those with incident AF (n = 96) were older, had a higher prevalence of cardiovascular disease and hypertension, and lower estimated glomerular filtration rate. After median follow-up of 6.8 years, we observed no significant multivariable association between incident AF and change in cognitive function test score. Conclusion: In this cohort of adults with CKD, incident AF was not associated with a decline in cognitive function.

Original language	English (US)
Pages (from-to)	669-674
Number of pages	6
Journal	Kidney International Reports
Volume	6
Issue number	3
DOIs	https://doi.org/10.1016/j.ekir.2020.12.023
State	Published - Mar 2021

Keywords

atrial fibrillation
cognitive function
nephrology and kidney

ASJC Scopus subject areas

Nephrology

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10.1016/j.ekir.2020.12.023

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@article{365523340e9c42258445fb537437068b,

title = "Atrial Fibrillation and Longitudinal Change in Cognitive Function in CKD",

abstract = "Background: Studies in the general population suggest that atrial fibrillation (AF) is an independent risk factor for decline in cognitive function, but this relationship has not been examined in adults with chronic kidney disease (CKD). We investigated the association between incident AF and changes in cognitive function over time in this population. Methods and Results: We studied a subgroup of 3254 adults participating in the Chronic Renal Insufficiency Cohort Study. Incident AF was ascertained by 12-lead electrocardiogram (ECG) obtained at a study visit and/or identification of a hospitalization with AF during follow-up. Cognitive function was assessed biennially using the Modified Mini-Mental State Exam. Linear mixed effects regression was used to evaluate the association between incident AF and longitudinal change in cognitive function. Compared with individuals without incident AF (n = 3158), those with incident AF (n = 96) were older, had a higher prevalence of cardiovascular disease and hypertension, and lower estimated glomerular filtration rate. After median follow-up of 6.8 years, we observed no significant multivariable association between incident AF and change in cognitive function test score. Conclusion: In this cohort of adults with CKD, incident AF was not associated with a decline in cognitive function.",

keywords = "atrial fibrillation, cognitive function, nephrology and kidney",

author = "{CRIC Study Investigators} and McCauley, {Mark D.} and Hsu, {Jesse Y.} and Ricardo, {Ana C.} and Dawood Darbar and Mayank Kansal and {Kurella Tamura}, Manjula and Feldman, {Harold I.} and Kusek, {John W.} and Taliercio, {Jonathan J.} and Rao, {Panduranga S.} and Tariq Shafi and Jiang He and Xue Wang and Daohang Sha and Melissa Lamar and Go, {Alan S.} and Kristine Yaffe and Lash, {James P.} and Appel, {Lawrence J.} and Mahboob Rahman and Townsend, {Raymond R.}",

note = "Publisher Copyright: {\textcopyright} 2021 International Society of Nephrology",

year = "2021",

month = mar,

doi = "10.1016/j.ekir.2020.12.023",

language = "English (US)",

volume = "6",

pages = "669--674",

journal = "Kidney International Reports",

issn = "2468-0249",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - Atrial Fibrillation and Longitudinal Change in Cognitive Function in CKD

AU - CRIC Study Investigators

AU - McCauley, Mark D.

AU - Hsu, Jesse Y.

AU - Ricardo, Ana C.

AU - Darbar, Dawood

AU - Kansal, Mayank

AU - Kurella Tamura, Manjula

AU - Feldman, Harold I.

AU - Kusek, John W.

AU - Taliercio, Jonathan J.

AU - Rao, Panduranga S.

AU - Shafi, Tariq

AU - He, Jiang

AU - Wang, Xue

AU - Sha, Daohang

AU - Lamar, Melissa

AU - Go, Alan S.

AU - Yaffe, Kristine

AU - Lash, James P.

AU - Appel, Lawrence J.

AU - Rahman, Mahboob

AU - Townsend, Raymond R.

PY - 2021/3

Y1 - 2021/3

N2 - Background: Studies in the general population suggest that atrial fibrillation (AF) is an independent risk factor for decline in cognitive function, but this relationship has not been examined in adults with chronic kidney disease (CKD). We investigated the association between incident AF and changes in cognitive function over time in this population. Methods and Results: We studied a subgroup of 3254 adults participating in the Chronic Renal Insufficiency Cohort Study. Incident AF was ascertained by 12-lead electrocardiogram (ECG) obtained at a study visit and/or identification of a hospitalization with AF during follow-up. Cognitive function was assessed biennially using the Modified Mini-Mental State Exam. Linear mixed effects regression was used to evaluate the association between incident AF and longitudinal change in cognitive function. Compared with individuals without incident AF (n = 3158), those with incident AF (n = 96) were older, had a higher prevalence of cardiovascular disease and hypertension, and lower estimated glomerular filtration rate. After median follow-up of 6.8 years, we observed no significant multivariable association between incident AF and change in cognitive function test score. Conclusion: In this cohort of adults with CKD, incident AF was not associated with a decline in cognitive function.

AB - Background: Studies in the general population suggest that atrial fibrillation (AF) is an independent risk factor for decline in cognitive function, but this relationship has not been examined in adults with chronic kidney disease (CKD). We investigated the association between incident AF and changes in cognitive function over time in this population. Methods and Results: We studied a subgroup of 3254 adults participating in the Chronic Renal Insufficiency Cohort Study. Incident AF was ascertained by 12-lead electrocardiogram (ECG) obtained at a study visit and/or identification of a hospitalization with AF during follow-up. Cognitive function was assessed biennially using the Modified Mini-Mental State Exam. Linear mixed effects regression was used to evaluate the association between incident AF and longitudinal change in cognitive function. Compared with individuals without incident AF (n = 3158), those with incident AF (n = 96) were older, had a higher prevalence of cardiovascular disease and hypertension, and lower estimated glomerular filtration rate. After median follow-up of 6.8 years, we observed no significant multivariable association between incident AF and change in cognitive function test score. Conclusion: In this cohort of adults with CKD, incident AF was not associated with a decline in cognitive function.

KW - atrial fibrillation

KW - cognitive function

KW - nephrology and kidney

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U2 - 10.1016/j.ekir.2020.12.023

DO - 10.1016/j.ekir.2020.12.023

M3 - Article

AN - SCOPUS:85101887888

SN - 2468-0249

VL - 6

SP - 669

EP - 674

JO - Kidney International Reports

JF - Kidney International Reports

IS - 3

ER -

Atrial Fibrillation and Longitudinal Change in Cognitive Function in CKD

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