ATM function and telomere stability

Tej K. Pandita

doi:10.1038/sj/onc/1205060

ATM function and telomere stability

Tej K. Pandita

Academic Institute

Research output: Contribution to journal › Review article › peer-review

154 Scopus citations

Abstract

Accumulation of DNA damage has been associated with the onset of senescence and predisposition to cancer. The gene responsible for ataxia telangiectasia (A-T) is ATM (ataxia-telangiectasia mutant), a master controller of cellular pathways and networks, orchestrating the responses to a specific type of DNA damage: the double strand break. Based on the homology of the human ATM gene to the TEL1, MEC1 and rad3 genes of yeast, it has now been demonstrated that mutations in ATM lead to defective telomere maintenance in mammalian cells. While ATM has both nuclear and cytoplasmic functions, this review will focus on its roles in telomere metabolism and how ATM and telomeres serve as controllers of cellular responses to DNA damage.

Original language	English (US)
Pages (from-to)	611-618
Number of pages	8
Journal	Oncogene
Volume	21
Issue number	4 REV. ISS. 1
DOIs	https://doi.org/10.1038/sj/onc/1205060
State	Published - Jan 21 2002

Keywords

ATM
DNA damage
hTERT
Signal transduction
Telomerase
Telomeres

ASJC Scopus subject areas

Molecular Biology
Cancer Research
Genetics

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10.1038/sj/onc/1205060

Cite this

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title = "ATM function and telomere stability",

abstract = "Accumulation of DNA damage has been associated with the onset of senescence and predisposition to cancer. The gene responsible for ataxia telangiectasia (A-T) is ATM (ataxia-telangiectasia mutant), a master controller of cellular pathways and networks, orchestrating the responses to a specific type of DNA damage: the double strand break. Based on the homology of the human ATM gene to the TEL1, MEC1 and rad3 genes of yeast, it has now been demonstrated that mutations in ATM lead to defective telomere maintenance in mammalian cells. While ATM has both nuclear and cytoplasmic functions, this review will focus on its roles in telomere metabolism and how ATM and telomeres serve as controllers of cellular responses to DNA damage.",

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author = "Pandita, {Tej K.}",

note = "Funding Information: I am grateful to the members of my laboratory for the comments on this manuscript. I regret being unable to cite many papers due to limited space. This work was supported by grants from the National Institute of Health (NS34746) and A-T Children's Project.",

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N2 - Accumulation of DNA damage has been associated with the onset of senescence and predisposition to cancer. The gene responsible for ataxia telangiectasia (A-T) is ATM (ataxia-telangiectasia mutant), a master controller of cellular pathways and networks, orchestrating the responses to a specific type of DNA damage: the double strand break. Based on the homology of the human ATM gene to the TEL1, MEC1 and rad3 genes of yeast, it has now been demonstrated that mutations in ATM lead to defective telomere maintenance in mammalian cells. While ATM has both nuclear and cytoplasmic functions, this review will focus on its roles in telomere metabolism and how ATM and telomeres serve as controllers of cellular responses to DNA damage.

AB - Accumulation of DNA damage has been associated with the onset of senescence and predisposition to cancer. The gene responsible for ataxia telangiectasia (A-T) is ATM (ataxia-telangiectasia mutant), a master controller of cellular pathways and networks, orchestrating the responses to a specific type of DNA damage: the double strand break. Based on the homology of the human ATM gene to the TEL1, MEC1 and rad3 genes of yeast, it has now been demonstrated that mutations in ATM lead to defective telomere maintenance in mammalian cells. While ATM has both nuclear and cytoplasmic functions, this review will focus on its roles in telomere metabolism and how ATM and telomeres serve as controllers of cellular responses to DNA damage.

KW - ATM

KW - DNA damage

KW - hTERT

KW - Signal transduction

KW - Telomerase

KW - Telomeres

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ATM function and telomere stability

Abstract

Keywords

ASJC Scopus subject areas

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