Atherogenesis and the arginine hypothesis.

J. P. Cooke; R. K. Oka

doi:10.1007/s11883-001-0068-x

Atherogenesis and the arginine hypothesis.

J. P. Cooke, R. K. Oka

Research output: Contribution to journal › Review article

51 Scopus citations

Abstract

In patients who have elevated levels of plasma ADMA, a relative deficiency of L-arginine has been found to contribute to the pathophysiology of athersclerosis, causing vasoconstriction, and accelerating atherogenesis. This finding--that there is a relative deficiency of L-arginine in atherosclerotic disease--is a breakthrough that will open new avenues of therapy.

Original language	English (US)
Pages (from-to)	252-259
Number of pages	8
Journal	Current Atherosclerosis Reports
Volume	3
Issue number	3
DOIs	https://doi.org/10.1007/s11883-001-0068-x
State	Published - May 2001

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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title = "Atherogenesis and the arginine hypothesis.",

abstract = "In patients who have elevated levels of plasma ADMA, a relative deficiency of L-arginine has been found to contribute to the pathophysiology of athersclerosis, causing vasoconstriction, and accelerating atherogenesis. This finding--that there is a relative deficiency of L-arginine in atherosclerotic disease--is a breakthrough that will open new avenues of therapy.",

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AB - In patients who have elevated levels of plasma ADMA, a relative deficiency of L-arginine has been found to contribute to the pathophysiology of athersclerosis, causing vasoconstriction, and accelerating atherogenesis. This finding--that there is a relative deficiency of L-arginine in atherosclerotic disease--is a breakthrough that will open new avenues of therapy.

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