TY - JOUR
T1 - Atherogenesis and the arginine hypothesis.
AU - Cooke, J. P.
AU - Oka, R. K.
N1 - Funding Information:
This manuscript was supported in part by grants from the National Heart, Lung and Blood Institute (R01 HL58638; to Dr. Cooke) and from the National Institute of Nursing Research (NR00150-02; to Dr Oka). Dr. Cooke is an Established Investigator of the American Heart Association. He is the founder of Cooke Pharma, maker of an arginine-enriched medical food.
Copyright:
This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PY - 2001/5
Y1 - 2001/5
N2 - In patients who have elevated levels of plasma ADMA, a relative deficiency of L-arginine has been found to contribute to the pathophysiology of athersclerosis, causing vasoconstriction, and accelerating atherogenesis. This finding--that there is a relative deficiency of L-arginine in atherosclerotic disease--is a breakthrough that will open new avenues of therapy.
AB - In patients who have elevated levels of plasma ADMA, a relative deficiency of L-arginine has been found to contribute to the pathophysiology of athersclerosis, causing vasoconstriction, and accelerating atherogenesis. This finding--that there is a relative deficiency of L-arginine in atherosclerotic disease--is a breakthrough that will open new avenues of therapy.
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U2 - 10.1007/s11883-001-0068-x
DO - 10.1007/s11883-001-0068-x
M3 - Review article
C2 - 11286647
AN - SCOPUS:0035344247
SN - 1523-3804
VL - 3
SP - 252
EP - 259
JO - Current Atherosclerosis Reports
JF - Current Atherosclerosis Reports
IS - 3
ER -