At least four loci and gender are associated with susceptibility to the chemical induction of lung adenomas in A/J x BALB/c mice

M. F.W. Festing, L. Lin, T. R. Devereux, F. Gao, A. Yang, C. H. Anna, C. M. White, A. M. Malkinson, M. You

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62 Scopus citations

Abstract

Four putative quantitative trait loci (QTLs) that influence susceptibility to the induction of lung adenomas by urethane in an F2 cross between A/J and BALB/cOlaHsd have been mapped. Following microsatellite typing of mice with resistant and susceptible phenotypes at 97 microsatellite marker loci, a major locus was identified on chromosome 18 with a lod score of 15. This was responsible for an 8- to 10-fold increase in tumor multiplicity in males and females, respectively, having the AA and CC genotypes at the D18Mit188 marker locus. It mapped close to Dcc (deleted in colorectal cancer). A locus on chromosome 4 (lod score 6.5) had the resistant allele in strain A/J and the susceptible allele in BALB/c, with a 14-fold difference in tumor multiplicity between mice of the AA and CC genotypes. This mapped close to the Cdkn2a (cyclin-dependent kinase inhibitor 2A) locus, which is commonly deleted in mouse lung tumors. Two loci with smaller effects (lod scores 3.03 and 3.25) were identified on chromosomes 1 and 11. There was also significant sexual dimorphism in tumor multiplicity both among 151 F2 hybrids and among 52 mice resulting from a backcross to strain A/J, with males having higher tumor counts than females.

Original languageEnglish (US)
Pages (from-to)129-136
Number of pages8
JournalGenomics
Volume53
Issue number2
DOIs
StatePublished - Oct 15 1998

ASJC Scopus subject areas

  • Genetics

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