Astrocyte responses after neonatal ischemia: the yin and the yang

Sonia Villapol, Antoinette Gelot, Sylvain Renolleau, Christiane Charriaut-Marlangue

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Neonatal encephalopathy is a major predictor of neurodevelopmental disability in term infants and occurs in 1 to 6 of every 1,000 live term births. Despite improvements in perinatal practice during the past several decades, the incidence of cerebral palsy attributed to neonatal asphyxia remained essentially unchanged, primarily because management strategies were supportive and not targeted toward the processes of ongoing injury. Traditionally, experimental research in vivo focused on neurons, and more recently, oligodendrocytes whereas astrocytes have been more or less neglected. This review aims at dissecting possible protective as well as destructive roles of astrocytes in the immature ischemic brain to stimulate further research into this unexplored aspect of brain pathophysiology.

Original languageEnglish (US)
Pages (from-to)339-44
Number of pages6
JournalNeuroscientist
Volume14
Issue number4
DOIs
StatePublished - Aug 2008

Keywords

  • Animals
  • Asphyxia Neonatorum
  • Astrocytes
  • Humans
  • Hypoxia-Ischemia, Brain
  • Infant
  • Infant, Newborn
  • Nerve Tissue Proteins
  • Journal Article
  • Review

Fingerprint Dive into the research topics of 'Astrocyte responses after neonatal ischemia: the yin and the yang'. Together they form a unique fingerprint.

Cite this