TY - JOUR
T1 - Asthma
T2 - Pathology and pathophysiology
AU - Barrios, Roberto
AU - Kheradmand, Farrah
AU - Batts, La Keisha
AU - Corry, David
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2006/4
Y1 - 2006/4
N2 - Context. - Asthma has been defined as a chronic inflammatory disorder of the airways that is associated with recruitment of inflammatory cells and the clinical development of wheezing, shortness of breath, chest tightness, and cough. Asthma is a major public health issue. It affects 5% of the United States population and accounts for 2 million emergency department visits, 470 000 hospitalizations, and 4500 deaths annually. Objective. - To review the pathophysiology and characteristic pathologic patterns of this disease and discuss the possible mechanisms of production of the lesions. Data Sources. - We searched the literature using MEDLINE and OVID. We also searched related conference abstracts and bibliographies of selected studies. Conclusions. - There has been a significant evolution in our understanding of asthma. Specific pathways and mechanisms in recent years have been studied; however, numerous mediators and cell receptors have raised new questions that remain to be answered.
AB - Context. - Asthma has been defined as a chronic inflammatory disorder of the airways that is associated with recruitment of inflammatory cells and the clinical development of wheezing, shortness of breath, chest tightness, and cough. Asthma is a major public health issue. It affects 5% of the United States population and accounts for 2 million emergency department visits, 470 000 hospitalizations, and 4500 deaths annually. Objective. - To review the pathophysiology and characteristic pathologic patterns of this disease and discuss the possible mechanisms of production of the lesions. Data Sources. - We searched the literature using MEDLINE and OVID. We also searched related conference abstracts and bibliographies of selected studies. Conclusions. - There has been a significant evolution in our understanding of asthma. Specific pathways and mechanisms in recent years have been studied; however, numerous mediators and cell receptors have raised new questions that remain to be answered.
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U2 - 10.5858/2006-130-447-apap
DO - 10.5858/2006-130-447-apap
M3 - Review article
C2 - 16594736
AN - SCOPUS:33645775249
SN - 0003-9985
VL - 130
SP - 447
EP - 451
JO - Archives of Pathology and Laboratory Medicine
JF - Archives of Pathology and Laboratory Medicine
IS - 4
ER -