Asthma, chronic obstructive pulmonary disease (COPD), and the overlap syndrome

Mohammad Obadah Nakawah, Clare Hawkins, Farouk Barbandi

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations


Asthma and chronic obstructive pulmonary disease (COPD) are highly prevalent chronic diseases in the general population. Both are characterized by heterogeneous chronic airway inflammation and airway obstruction. In both conditions, chronic inflammation affects the whole respiratory tract, from central to peripheral airways, with different inflammatory cells recruited, different mediators produced, and thus differing responses to therapy. Airway obstruction is typically intermittent and reversible in asthma but is progressive and largely irreversible in COPD. However, there is a considerable pathologic and functional overlap between these 2 heterogeneous disorders, particularly among the elderly, who may have components of both diseases (asthma-COPD overlap syndrome). The definitions for asthma and COPD recommended by current guidelines are useful but limited because they do not illustrate the full spectrum of obstructive airway diseases that is encountered in clinical practice. Defining asthma and COPD as separate entities neglects a considerable proportion of patients with overlapping features and is largely based on expert opinion rather than on the best current evidence. The presence of different phenotypes or components of obstructive airway diseases, therefore, needs to be addressed to individualize and optimize treatment to achieve the best effect with the fewest side effects for the patient. Although specific interventions vary by disease, the treatment goals of obstructive airway diseases are similar and driven primarily by the need to control symptoms, optimize health status, and prevent exacerbations. ( J Am Board Fam Med 2013;26: 470 - 477.).

Original languageEnglish (US)
Pages (from-to)470-477
Number of pages8
JournalJournal of the American Board of Family Medicine
Issue number4
StatePublished - Jul 2013


  • Asthma
  • COPD
  • Chronic obstructive airway diseases
  • Overlap syndrome

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Family Practice


Dive into the research topics of 'Asthma, chronic obstructive pulmonary disease (COPD), and the overlap syndrome'. Together they form a unique fingerprint.

Cite this