Assuring the proper analytical performance of measurement procedures for immunosuppressive drug concentrations in clinical practice: Recommendations of the international association of therapeutic drug monitoring and clinical toxicology immunosuppressive drug scientific committee

Christoph Seger, Maria Shipkova, Uwe Christians, Elaine M. Billaud, Ping Wang, David W. Holt, Merce Brunet, Pawe K. Kunicki, Thomasz Pawinski, Loralie J. Langman, Pierre Marquet, Michael Oellerich, Eberhard Wieland, Pierre Wallemacq

Research output: Contribution to journalReview article

43 Scopus citations

Abstract

Monitoring immunosuppressive drugs (ISDs) in blood or plasma is still a key therapeutic drug monitoring (TDM) application in clinical settings. Narrow target ranges and severe side effects at drug underexposure or overexposure make accurate and precise measurements a must. This overview prepared by the Immunosuppressive Drugs Scientific Committee of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology is intended to serve as a summary and guidance document describing the current state-of-the-art in the TDM of ISDs.

Original languageEnglish (US)
Pages (from-to)170-189
Number of pages20
JournalTherapeutic Drug Monitoring
Volume38
Issue number2
DOIs
StatePublished - 2016

Keywords

  • Cyclosporine
  • Design
  • Everolimus
  • Immunoassay
  • Immunosuppressant drugs
  • LC-MS/MS
  • Mycophenolic acid
  • Sirolimus
  • TDM
  • Tacrolimus
  • Validation
  • Verification

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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