TY - JOUR
T1 - Associations between aspirin and other non-steroidal anti-inflammatory drugs and aortic valve or coronary artery calcification
T2 - The multi-ethnic study of atherosclerosis and the heinz nixdorf recall study
AU - Delaney, Joseph A.
AU - Lehmann, Nils
AU - Jöckel, Karl Heinz
AU - Elmariah, Sammy
AU - Psaty, Bruce M.
AU - Mahabadi, Amir A.
AU - Budoff, Matt
AU - Kronmal, Richard A.
AU - Nasir, Khurram
AU - O'Brien, Kevin D.
AU - Möhlenkamp, Stefan
AU - Moebus, Susanne
AU - Dragano, Nico
AU - Winterstein, Almut G.
AU - Erbel, Raimund
AU - Kälsch, Hagen
N1 - Funding Information:
The Heinz Nixdorf Recall Study is funded by a contract with the private Heinz Nixdorf Foundation, Essen, Germany and undergoes continuous monitoring by governmental agencies (DLR) lead by the Bundesministerium für Bildung und Forschung (BMBF). This research is also supported by the Deutsche Forschungsgemeinschaft (DFG) and by the American Association of Colleges of Pharmacy through their New Pharmacy Faculty Research Awards Program.
Funding Information:
This research was supported by R01-HL071739 and contracts N01-HC-95159 through N01-HC-95165 and N01-HC-95169 from the National Heart, Lung, and Blood Institute . The authors thank the other investigators, the staff, and the participants of the MESA and HNR studies for their valuable contributions. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org . This study was also supported by a New Pharmacy Faculty Research Award from the American Association of Colleges of Pharmacy (Delaney).
Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2013/8
Y1 - 2013/8
N2 - Background: The association between non-steroidal anti-inflammatory drugs (NSAIDs) and the incidence of valvular and arterial calcification is not well established despite known associations between these drugs and cardiovascular events. Objective: To compare the association between the baseline use of aspirin with other NSAID class medications with the incidence and prevalence of aortic valve calcification (AVC) and coronary artery calcification (CAC). Methods: The relationship of NSAID use to AVC and CAC detected by computed tomography was assessed in 6814 participants within the Multi-Ethnic Study of Atherosclerosis (MESA) using regression modeling. Results were adjusted for age, sex, ethnicity, study site, anti-hypertensive medication use, education, income, health insurance status, diabetes, smoking, exercise, body mass index, blood pressure, serum lipids, inflammatory markers, fasting glucose, statin medication use, and a simple diet score. Medication use was assessed by medication inventory at baseline which includes the use of non-prescription NSAIDs. MESA collects information on both incident and prevalent calcification. The 4814 participants of the Heinz Nixdorf Recall (HNR) Study, a German prospective cohort study with similar measures of calcification, were included in this analysis to enable replication. Results: Mean age of the MESA participants was 62 years (51% female). After adjustment for possible confounding factors, a possible association between aspirin use and incident AVC (Relative Risk(RR): 1.60; 95%Confidence Interval (CI): 1.19-2.15) did not replicate in the HNR cohort (RR: 1.06; 95%CI: 0.87-1.28). There was no significant association between aspirin use and incident CAC in the MESA cohort (RR 1.08; 95%CI: 0.91-1.29) or in the HNR cohort (RR 1.24; 95%CI: 0.87-1.77). Non-aspirin NSAID use was not associated with either AVC or CAC in either cohort. There were no associations between regular cardiac dose aspirin and incident calcification in either cohort. Conclusion: Baseline NSAID use, as assessed by medication inventory, appears to have no protective effect regarding the onset of calcification in either coronary arteries or aortic valves.
AB - Background: The association between non-steroidal anti-inflammatory drugs (NSAIDs) and the incidence of valvular and arterial calcification is not well established despite known associations between these drugs and cardiovascular events. Objective: To compare the association between the baseline use of aspirin with other NSAID class medications with the incidence and prevalence of aortic valve calcification (AVC) and coronary artery calcification (CAC). Methods: The relationship of NSAID use to AVC and CAC detected by computed tomography was assessed in 6814 participants within the Multi-Ethnic Study of Atherosclerosis (MESA) using regression modeling. Results were adjusted for age, sex, ethnicity, study site, anti-hypertensive medication use, education, income, health insurance status, diabetes, smoking, exercise, body mass index, blood pressure, serum lipids, inflammatory markers, fasting glucose, statin medication use, and a simple diet score. Medication use was assessed by medication inventory at baseline which includes the use of non-prescription NSAIDs. MESA collects information on both incident and prevalent calcification. The 4814 participants of the Heinz Nixdorf Recall (HNR) Study, a German prospective cohort study with similar measures of calcification, were included in this analysis to enable replication. Results: Mean age of the MESA participants was 62 years (51% female). After adjustment for possible confounding factors, a possible association between aspirin use and incident AVC (Relative Risk(RR): 1.60; 95%Confidence Interval (CI): 1.19-2.15) did not replicate in the HNR cohort (RR: 1.06; 95%CI: 0.87-1.28). There was no significant association between aspirin use and incident CAC in the MESA cohort (RR 1.08; 95%CI: 0.91-1.29) or in the HNR cohort (RR 1.24; 95%CI: 0.87-1.77). Non-aspirin NSAID use was not associated with either AVC or CAC in either cohort. There were no associations between regular cardiac dose aspirin and incident calcification in either cohort. Conclusion: Baseline NSAID use, as assessed by medication inventory, appears to have no protective effect regarding the onset of calcification in either coronary arteries or aortic valves.
KW - Aortic valve calcification
KW - Aspirin
KW - Coronary artery calcification
KW - Heinz Nixdorf Recall Study
KW - Multi-Ethnic Study of Atherosclerosis
KW - Non-steroidal anti-inflammatory drugs
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U2 - 10.1016/j.atherosclerosis.2013.05.002
DO - 10.1016/j.atherosclerosis.2013.05.002
M3 - Article
C2 - 23880181
AN - SCOPUS:84880417271
VL - 229
SP - 310
EP - 316
JO - Atherosclerosis
JF - Atherosclerosis
SN - 0021-9150
IS - 2
ER -