TY - JOUR
T1 - Association of transforming growth factor-β1 with prostate cancer
T2 - An immunohistochemical study
AU - Truong, Luan
AU - Kadmon, Dov
AU - McCune, Bryan K.
AU - Flanders, Kathleen C.
AU - Scardino, Peter T.
AU - Thompson, Timothy C.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - Prostate tissue samples from patients with prostatic carcinoma (PC) and/or benign prostatic hyperplasia (BPH) were examined for expression of transforming growth factor-β1 (TGF-β1) using an immunohistochemical technique. Tissues were stained with CC and LC antisera, which react with extracellular and intracellular TGF-β1, respectively. All PC and BPH tissues showed positive extracellular staining; however, CC-immunoreactive material was significantly more extensive in PC compared with BPH, the average positively staining areas being 59% and 26%, respectively. This differential staining pattern was evident in cases in which areas of PC were located adjacent to areas of BPH. LC staining was identified exclusively intracellularly involving both stromal and epithelial cells in cases of PC as well as BPH. However, while stromal cell staining was more pronounced in BPH, epithelial cell staining tended to be more extensive and more intense in PC. The findings suggest that TGF-β1 may be biologically important in the development of PC and BPH.
AB - Prostate tissue samples from patients with prostatic carcinoma (PC) and/or benign prostatic hyperplasia (BPH) were examined for expression of transforming growth factor-β1 (TGF-β1) using an immunohistochemical technique. Tissues were stained with CC and LC antisera, which react with extracellular and intracellular TGF-β1, respectively. All PC and BPH tissues showed positive extracellular staining; however, CC-immunoreactive material was significantly more extensive in PC compared with BPH, the average positively staining areas being 59% and 26%, respectively. This differential staining pattern was evident in cases in which areas of PC were located adjacent to areas of BPH. LC staining was identified exclusively intracellularly involving both stromal and epithelial cells in cases of PC as well as BPH. However, while stromal cell staining was more pronounced in BPH, epithelial cell staining tended to be more extensive and more intense in PC. The findings suggest that TGF-β1 may be biologically important in the development of PC and BPH.
KW - prostate nodular hyperplasia
KW - transforming growth factor-β prostate cancer
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U2 - 10.1016/0046-8177(93)90055-L
DO - 10.1016/0046-8177(93)90055-L
M3 - Article
C2 - 7678092
AN - SCOPUS:0027511966
VL - 24
SP - 4
EP - 9
JO - Human Pathology
JF - Human Pathology
SN - 0046-8177
IS - 1
ER -