TY - JOUR
T1 - Association of transforming growth factor-β1 with prostate cancer
T2 - An immunohistochemical study
AU - Truong, Luan D.
AU - Kadmon, Dov
AU - McCune, Bryan K.
AU - Flanders, Kathleen C.
AU - Scardino, Peter T.
AU - Thompson, Timothy C.
N1 - Funding Information:
From the Department of Pathology, The Methodist Hospital, and the Scott Department of Urology and the Department of Cell Biology, Baylor College of Medicine, Houston, TX; the Urology Research Laboratory, Veterans Affairs Medical Center, Houston, TX; and the Chemoprevention Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD. Accepted for publiration April 20, 1992. Supported in part by a grant (CA50588) from the National Institutes of Health and the Veterans Affairs Medical Center. Key words: transforming growth factor-p, prostate cancer, prostate nodular hyperplasia. Address correspondence and reprint requests to Timothy C. Thompson, PhD, Scott Department of Urology, Baylor College of Medicine, 6535 Fannin, F427A, Houston, TX 77030. Copyright 0 1993 by W.B. Saunders Company 0046~8177/93/2401-0002$5.00/O
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1993/1
Y1 - 1993/1
N2 - Prostate tissue samples from patients with prostatic carcinoma (PC) and/or benign prostatic hyperplasia (BPH) were examined for expression of transforming growth factor-β1 (TGF-β1) using an immunohistochemical technique. Tissues were stained with CC and LC antisera, which react with extracellular and intracellular TGF-β1, respectively. All PC and BPH tissues showed positive extracellular staining; however, CC-immunoreactive material was significantly more extensive in PC compared with BPH, the average positively staining areas being 59% and 26%, respectively. This differential staining pattern was evident in cases in which areas of PC were located adjacent to areas of BPH. LC staining was identified exclusively intracellularly involving both stromal and epithelial cells in cases of PC as well as BPH. However, while stromal cell staining was more pronounced in BPH, epithelial cell staining tended to be more extensive and more intense in PC. The findings suggest that TGF-β1 may be biologically important in the development of PC and BPH.
AB - Prostate tissue samples from patients with prostatic carcinoma (PC) and/or benign prostatic hyperplasia (BPH) were examined for expression of transforming growth factor-β1 (TGF-β1) using an immunohistochemical technique. Tissues were stained with CC and LC antisera, which react with extracellular and intracellular TGF-β1, respectively. All PC and BPH tissues showed positive extracellular staining; however, CC-immunoreactive material was significantly more extensive in PC compared with BPH, the average positively staining areas being 59% and 26%, respectively. This differential staining pattern was evident in cases in which areas of PC were located adjacent to areas of BPH. LC staining was identified exclusively intracellularly involving both stromal and epithelial cells in cases of PC as well as BPH. However, while stromal cell staining was more pronounced in BPH, epithelial cell staining tended to be more extensive and more intense in PC. The findings suggest that TGF-β1 may be biologically important in the development of PC and BPH.
KW - prostate nodular hyperplasia
KW - transforming growth factor-β prostate cancer
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U2 - 10.1016/0046-8177(93)90055-L
DO - 10.1016/0046-8177(93)90055-L
M3 - Article
C2 - 7678092
AN - SCOPUS:0027511966
VL - 24
SP - 4
EP - 9
JO - Human Pathology
JF - Human Pathology
SN - 0046-8177
IS - 1
ER -