Association of neighborhood deprivation with Alzheimer's Disease pathologies, gray matter volume, white matter hyperintensities and cognition by sex, race or ethnicity and APOE4 status in Non-demented Older Adults

Pablo Aguilar; Thomas Monroe Holland; Sam N. Lockhart; Joseph C. Masdeu; Lycia Tramujas Vasconcellos Neumann; Heather M Snyder; Laura D Baker; Susan M. Landau; Eider M Arenaza-Urquijo

doi:10.1002/alz70860_105535

Association of neighborhood deprivation with Alzheimer's Disease pathologies, gray matter volume, white matter hyperintensities and cognition by sex, race or ethnicity and APOE4 status in Non-demented Older Adults

Pablo Aguilar, Thomas Monroe Holland, Sam N. Lockhart, Joseph C. Masdeu, Lycia Tramujas Vasconcellos Neumann, Heather M Snyder, Laura D Baker, Susan M. Landau, Eider M Arenaza-Urquijo

Research output: Contribution to journal › Article › peer-review

Abstract

Abstract Background Neighborhood socio-economic conditions may increase Alzheimer's disease (AD) risk through amyloid, tau, atrophy or vascular pathways, potentially varying by genetic risk, race or ethnicity and sex. We examined associations between Area Deprivation Index (ADI) and cognition, AD pathology, gray matter (GM) and white matter hyperintensities (WMH) volume in cognitively unimpaired older adults by race or ethnicity, sex and APOE4 status. Method We included 1896 non-demented older adults from US POINTER study with available cognitive evaluations, ADI level ? a census?based neighborhood disadvantage metric (categorized as low, moderate and high) and a subsample with neuroimaging data (N = 806). Linear/logistic regressions were used to assess interactions of ADI with sex, race or ethnicity, and APOE4 on (1) the Preclinical Alzheimer's Cognitive Composite, (PACC-5), (2) MRI-derived GM volume meta-ROI (entorhinal, fusiform, parahippocampal, mid-temporal, inferior temporal), (3) WMH and (4) AD pathology (amyloid and tau PET), adjusted by age, sex and intracranial volume when appropriate. Result African American participants (p

Original language	English (US)
Pages (from-to)	e105535
Journal	Alzheimer's and Dementia
Volume	21
Issue number	S6
DOIs	https://doi.org/10.1002/alz70860_105535
State	Published - Dec 23 2025

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Aguilar, P., Holland, T. M., Lockhart, S. N., Masdeu, J. C., Neumann, L. T. V., Snyder, H. M., Baker, L. D., Landau, S. M., & Arenaza-Urquijo, E. M. (2025). Association of neighborhood deprivation with Alzheimer's Disease pathologies, gray matter volume, white matter hyperintensities and cognition by sex, race or ethnicity and APOE4 status in Non-demented Older Adults. Alzheimer's and Dementia, 21(S6), e105535. https://doi.org/10.1002/alz70860_105535

Association of neighborhood deprivation with Alzheimer's Disease pathologies, gray matter volume, white matter hyperintensities and cognition by sex, race or ethnicity and APOE4 status in Non-demented Older Adults. / Aguilar, Pablo; Holland, Thomas Monroe; Lockhart, Sam N. et al.
In: Alzheimer's and Dementia, Vol. 21, No. S6, 23.12.2025, p. e105535.

Research output: Contribution to journal › Article › peer-review

Aguilar, P, Holland, TM, Lockhart, SN, Masdeu, JC, Neumann, LTV, Snyder, HM, Baker, LD, Landau, SM & Arenaza-Urquijo, EM 2025, 'Association of neighborhood deprivation with Alzheimer's Disease pathologies, gray matter volume, white matter hyperintensities and cognition by sex, race or ethnicity and APOE4 status in Non-demented Older Adults', Alzheimer's and Dementia, vol. 21, no. S6, pp. e105535. https://doi.org/10.1002/alz70860_105535

Aguilar P, Holland TM, Lockhart SN, Masdeu JC, Neumann LTV, Snyder HM et al. Association of neighborhood deprivation with Alzheimer's Disease pathologies, gray matter volume, white matter hyperintensities and cognition by sex, race or ethnicity and APOE4 status in Non-demented Older Adults. Alzheimer's and Dementia. 2025 Dec 23;21(S6):e105535. doi: 10.1002/alz70860_105535

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title = "Association of neighborhood deprivation with Alzheimer's Disease pathologies, gray matter volume, white matter hyperintensities and cognition by sex, race or ethnicity and APOE4 status in Non-demented Older Adults",

abstract = "Abstract Background Neighborhood socio-economic conditions may increase Alzheimer's disease (AD) risk through amyloid, tau, atrophy or vascular pathways, potentially varying by genetic risk, race or ethnicity and sex. We examined associations between Area Deprivation Index (ADI) and cognition, AD pathology, gray matter (GM) and white matter hyperintensities (WMH) volume in cognitively unimpaired older adults by race or ethnicity, sex and APOE4 status. Method We included 1896 non-demented older adults from US POINTER study with available cognitive evaluations, ADI level ? a census?based neighborhood disadvantage metric (categorized as low, moderate and high) and a subsample with neuroimaging data (N = 806). Linear/logistic regressions were used to assess interactions of ADI with sex, race or ethnicity, and APOE4 on (1) the Preclinical Alzheimer's Cognitive Composite, (PACC-5), (2) MRI-derived GM volume meta-ROI (entorhinal, fusiform, parahippocampal, mid-temporal, inferior temporal), (3) WMH and (4) AD pathology (amyloid and tau PET), adjusted by age, sex and intracranial volume when appropriate. Result African American participants (p ",

author = "Pablo Aguilar and Holland, \{Thomas Monroe\} and Lockhart, \{Sam N.\} and Masdeu, \{Joseph C.\} and Neumann, \{Lycia Tramujas Vasconcellos\} and Snyder, \{Heather M\} and Baker, \{Laura D\} and Landau, \{Susan M.\} and Arenaza-Urquijo, \{Eider M\}",

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doi = "10.1002/alz70860\_105535",

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AU - Aguilar, Pablo

AU - Holland, Thomas Monroe

AU - Lockhart, Sam N.

AU - Masdeu, Joseph C.

AU - Neumann, Lycia Tramujas Vasconcellos

AU - Snyder, Heather M

AU - Baker, Laura D

AU - Landau, Susan M.

AU - Arenaza-Urquijo, Eider M

PY - 2025/12/23

Y1 - 2025/12/23

N2 - Abstract Background Neighborhood socio-economic conditions may increase Alzheimer's disease (AD) risk through amyloid, tau, atrophy or vascular pathways, potentially varying by genetic risk, race or ethnicity and sex. We examined associations between Area Deprivation Index (ADI) and cognition, AD pathology, gray matter (GM) and white matter hyperintensities (WMH) volume in cognitively unimpaired older adults by race or ethnicity, sex and APOE4 status. Method We included 1896 non-demented older adults from US POINTER study with available cognitive evaluations, ADI level ? a census?based neighborhood disadvantage metric (categorized as low, moderate and high) and a subsample with neuroimaging data (N = 806). Linear/logistic regressions were used to assess interactions of ADI with sex, race or ethnicity, and APOE4 on (1) the Preclinical Alzheimer's Cognitive Composite, (PACC-5), (2) MRI-derived GM volume meta-ROI (entorhinal, fusiform, parahippocampal, mid-temporal, inferior temporal), (3) WMH and (4) AD pathology (amyloid and tau PET), adjusted by age, sex and intracranial volume when appropriate. Result African American participants (p

AB - Abstract Background Neighborhood socio-economic conditions may increase Alzheimer's disease (AD) risk through amyloid, tau, atrophy or vascular pathways, potentially varying by genetic risk, race or ethnicity and sex. We examined associations between Area Deprivation Index (ADI) and cognition, AD pathology, gray matter (GM) and white matter hyperintensities (WMH) volume in cognitively unimpaired older adults by race or ethnicity, sex and APOE4 status. Method We included 1896 non-demented older adults from US POINTER study with available cognitive evaluations, ADI level ? a census?based neighborhood disadvantage metric (categorized as low, moderate and high) and a subsample with neuroimaging data (N = 806). Linear/logistic regressions were used to assess interactions of ADI with sex, race or ethnicity, and APOE4 on (1) the Preclinical Alzheimer's Cognitive Composite, (PACC-5), (2) MRI-derived GM volume meta-ROI (entorhinal, fusiform, parahippocampal, mid-temporal, inferior temporal), (3) WMH and (4) AD pathology (amyloid and tau PET), adjusted by age, sex and intracranial volume when appropriate. Result African American participants (p

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