Association of cognitive function with amyloid-β and tau proteins in the vitreous humor

Lauren M. Wright, Thor D. Stein, Gyungah Jun, Jaeyoon Chung, Kate McConnell, Marissa Fiorello, Nicole Siegel, Steven Ness, Weiming Xia, Kelley L. Turner, Manju L. Subramanian

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Background: The eye may serve as source for diagnostic testing for early detection of Alzheimer's disease (AD). Examination of amyloid-β (A-β) and tau protein content in human vitreous and its correlation to neuro-cognition may improve ocular-based AD detection methods. Objective: To evaluate levels of A-β and tau protein in human vitreous humor and investigate the clinical predictive role of these proteins as early diagnostic markers of AD. Methods: A prospective, single-center, multi-surgeon cohort study. Vitreous humor samples from 80 eyes were measured quantitatively for A-β40-42, pTau, and tTau. Linear regression was used to test associations between AD biomarker levels, Mini-Mental State Exam (MMSE), and serum apolipoprotein E (APOE) allele status, with adjustment for age, sex, and education level of patients. Results: LowerMMSEscores were significantly associated with lower levels of vitreous A-β 40 (p = 0.015), A-β 42 (p = 0.0066), and tTau (p = 0.0085), and these biomarkers were not associated with any pre-existing eye conditions. Presence of the-β4 allele and the-β2 allele approached significance with reduced A-β 40 level (p = 0.053) and increased p-Tau level (p = 0.056), respectively.

Original languageEnglish (US)
Pages (from-to)1429-1438
Number of pages10
JournalJournal of Alzheimer's Disease
Volume68
Issue number4
DOIs
StatePublished - 2019

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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