Association of circulating cell-free double-stranded DNA and metabolic derangements in idiopathic pulmonary fibrosis

William Whalen; Mustafa Buyukozkan; Bethany Moore; Jong Seok Moon; Charles S. Dela Cruz; Fernando J. Martinez; Augustine M.K. Choi; Jan Krumsiek; Heather Stout-Delgado; Soo Jung Cho

doi:10.1136/thoraxjnl-2021-217315

Association of circulating cell-free double-stranded DNA and metabolic derangements in idiopathic pulmonary fibrosis

William Whalen, Mustafa Buyukozkan, Bethany Moore, Jong Seok Moon, Charles S. Dela Cruz, Fernando J. Martinez, Augustine M.K. Choi, Jan Krumsiek, Heather Stout-Delgado, Soo Jung Cho

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with unclear aetiology and poorly understood pathophysiology. Although plasma levels of circulating cell-free DNA (ccf-DNA) and metabolomic changes have been reported in IPF, the associations between ccf-DNA levels and metabolic derangements in lung fibrosis are unclear. Here, we demonstrate that ccfdouble-stranded DNA (dsDNA) is increased in patients with IPF with rapid progression of disease compared with slow progressors and healthy controls and that ccf-dsDNA associates with amino acid metabolism, energy metabolism and lipid metabolism pathways in patients with IPF.

Original language	English (US)
Pages (from-to)	186-190
Number of pages	5
Journal	Thorax
Volume	77
Issue number	2
DOIs	https://doi.org/10.1136/thoraxjnl-2021-217315
State	Published - Feb 2022

Keywords

idiopathic pulmonary fibrosis
Metabolomics
Cell-Free Nucleic Acids
DNA
Humans
Idiopathic Pulmonary Fibrosis
Disease Progression

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1136/thoraxjnl-2021-217315

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title = "Association of circulating cell-free double-stranded DNA and metabolic derangements in idiopathic pulmonary fibrosis",

abstract = "Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with unclear aetiology and poorly understood pathophysiology. Although plasma levels of circulating cell-free DNA (ccf-DNA) and metabolomic changes have been reported in IPF, the associations between ccf-DNA levels and metabolic derangements in lung fibrosis are unclear. Here, we demonstrate that ccfdouble-stranded DNA (dsDNA) is increased in patients with IPF with rapid progression of disease compared with slow progressors and healthy controls and that ccf-dsDNA associates with amino acid metabolism, energy metabolism and lipid metabolism pathways in patients with IPF.",

keywords = "idiopathic pulmonary fibrosis, Metabolomics, Cell-Free Nucleic Acids, DNA, Humans, Idiopathic Pulmonary Fibrosis, Disease Progression",

author = "William Whalen and Mustafa Buyukozkan and Bethany Moore and Moon, {Jong Seok} and {Dela Cruz}, {Charles S.} and Martinez, {Fernando J.} and Choi, {Augustine M.K.} and Jan Krumsiek and Heather Stout-Delgado and Cho, {Soo Jung}",

note = "{\textcopyright} Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",

year = "2022",

month = feb,

doi = "10.1136/thoraxjnl-2021-217315",

language = "English (US)",

volume = "77",

pages = "186--190",

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TY - JOUR

T1 - Association of circulating cell-free double-stranded DNA and metabolic derangements in idiopathic pulmonary fibrosis

AU - Whalen, William

AU - Buyukozkan, Mustafa

AU - Moore, Bethany

AU - Moon, Jong Seok

AU - Dela Cruz, Charles S.

AU - Martinez, Fernando J.

AU - Choi, Augustine M.K.

AU - Krumsiek, Jan

AU - Stout-Delgado, Heather

AU - Cho, Soo Jung

N1 - © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2022/2

Y1 - 2022/2

N2 - Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with unclear aetiology and poorly understood pathophysiology. Although plasma levels of circulating cell-free DNA (ccf-DNA) and metabolomic changes have been reported in IPF, the associations between ccf-DNA levels and metabolic derangements in lung fibrosis are unclear. Here, we demonstrate that ccfdouble-stranded DNA (dsDNA) is increased in patients with IPF with rapid progression of disease compared with slow progressors and healthy controls and that ccf-dsDNA associates with amino acid metabolism, energy metabolism and lipid metabolism pathways in patients with IPF.

AB - Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with unclear aetiology and poorly understood pathophysiology. Although plasma levels of circulating cell-free DNA (ccf-DNA) and metabolomic changes have been reported in IPF, the associations between ccf-DNA levels and metabolic derangements in lung fibrosis are unclear. Here, we demonstrate that ccfdouble-stranded DNA (dsDNA) is increased in patients with IPF with rapid progression of disease compared with slow progressors and healthy controls and that ccf-dsDNA associates with amino acid metabolism, energy metabolism and lipid metabolism pathways in patients with IPF.

KW - idiopathic pulmonary fibrosis

KW - Metabolomics

KW - Cell-Free Nucleic Acids

KW - DNA

KW - Humans

KW - Idiopathic Pulmonary Fibrosis

KW - Disease Progression

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U2 - 10.1136/thoraxjnl-2021-217315

DO - 10.1136/thoraxjnl-2021-217315

M3 - Article

C2 - 34521729

AN - SCOPUS:85123649815

SN - 0040-6376

VL - 77

SP - 186

EP - 190

JO - Thorax

JF - Thorax

IS - 2

ER -

Association of circulating cell-free double-stranded DNA and metabolic derangements in idiopathic pulmonary fibrosis

Abstract

Keywords

ASJC Scopus subject areas

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