Association of body mass index with arterial stiffness and blood pressure components: A twin study

Research output: Contribution to journalArticle

Adam Domonkos Tarnoki, David Laszlo Tarnoki, Leonie H. Bogl, Emanuela Medda, Corrado Fagnani, Lorenza Nisticò, Maria Antonietta Stazi, Sonia Brescianini, Pierleone Lucatelli, Emanuele Boatta, Chiara Zini, Fabrizio Fanelli, Claudio Baracchini, Giorgio Meneghetti, Janos Osztovits, Gyorgy Jermendy, Robert Gabor Kiss, Istvan Preda, Kinga Karlinger, Agnes Lannert & 8 others Andrea Agnes Molnar, Levente Littvay, Zsolt Garami, Viktor Berczi, Giacomo Pucci, Gyorgy Baffy, Giuseppe Schillaci, Kirsi H. Pietiläinen

Rationale: Obesity, blood pressure and arterial stiffness are heritable traits interconnected to each other but their possible common genetic and environmental etiologies are unknown. Methods: We studied 228 monozygotic and 150 dizygotic twin pairs aged 18-82 years from Italy, Hungary and the United States, of which 45 monozygotic and 38 dizygotic pairs were discordant for body mass index (BMI; intrapair difference (δ) in BMI≥3kg/m2). Blood pressure components and arterial stiffness were measured by TensioMed Arteriograph. Results: Hypertension was more prevalent among obese than non-obese individuals (55% vs. 29%, p<0.001). Age-, sex- and country-adjusted heritability estimates were high for hemodynamic measures (45%-58%) and BMI (78%). According to bivariate Cholesky decomposition, phenotypic correlations between BMI and blood pressure components (r=-0.15 to 0.24, p<0.05) were largely explained by additive genetic factors (65%-77%) with the remaining explained by the unique environment. When controlling for genetic factors within all monozygotic pairs, δBMI was significantly correlated with δbrachial systolic blood pressure (SBP) and diastolic blood pressure (DBP), δmean arterial pressure, and δaortic SBP (r=0.15-0.17, p<0.05). For the same measures, heavier co-twins of BMI-discordant monozygotic pairs had significantly higher values than their leaner counterparts (p<0.05).

Original languageEnglish
Pages (from-to)388-395
Number of pages8
JournalAtherosclerosis
Volume229
Issue number2
DOIs
StatePublished - Aug 1 2013

PMID: 23880193

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Association of body mass index with arterial stiffness and blood pressure components : A twin study. / Tarnoki, Adam Domonkos; Tarnoki, David Laszlo; Bogl, Leonie H.; Medda, Emanuela; Fagnani, Corrado; Nisticò, Lorenza; Stazi, Maria Antonietta; Brescianini, Sonia; Lucatelli, Pierleone; Boatta, Emanuele; Zini, Chiara; Fanelli, Fabrizio; Baracchini, Claudio; Meneghetti, Giorgio; Osztovits, Janos; Jermendy, Gyorgy; Kiss, Robert Gabor; Preda, Istvan; Karlinger, Kinga; Lannert, Agnes; Molnar, Andrea Agnes; Littvay, Levente; Garami, Zsolt; Berczi, Viktor; Pucci, Giacomo; Baffy, Gyorgy; Schillaci, Giuseppe; Pietiläinen, Kirsi H.

In: Atherosclerosis, Vol. 229, No. 2, 01.08.2013, p. 388-395.

Research output: Contribution to journalArticle

Harvard

Tarnoki, AD, Tarnoki, DL, Bogl, LH, Medda, E, Fagnani, C, Nisticò, L, Stazi, MA, Brescianini, S, Lucatelli, P, Boatta, E, Zini, C, Fanelli, F, Baracchini, C, Meneghetti, G, Osztovits, J, Jermendy, G, Kiss, RG, Preda, I, Karlinger, K, Lannert, A, Molnar, AA, Littvay, L, Garami, Z, Berczi, V, Pucci, G, Baffy, G, Schillaci, G & Pietiläinen, KH 2013, 'Association of body mass index with arterial stiffness and blood pressure components: A twin study' Atherosclerosis, vol. 229, no. 2, pp. 388-395. https://doi.org/10.1016/j.atherosclerosis.2013.05.001

APA

Tarnoki, A. D., Tarnoki, D. L., Bogl, L. H., Medda, E., Fagnani, C., Nisticò, L., ... Pietiläinen, K. H. (2013). Association of body mass index with arterial stiffness and blood pressure components: A twin study. Atherosclerosis, 229(2), 388-395. https://doi.org/10.1016/j.atherosclerosis.2013.05.001

Vancouver

Tarnoki AD, Tarnoki DL, Bogl LH, Medda E, Fagnani C, Nisticò L et al. Association of body mass index with arterial stiffness and blood pressure components: A twin study. Atherosclerosis. 2013 Aug 1;229(2):388-395. https://doi.org/10.1016/j.atherosclerosis.2013.05.001

Author

Tarnoki, Adam Domonkos ; Tarnoki, David Laszlo ; Bogl, Leonie H. ; Medda, Emanuela ; Fagnani, Corrado ; Nisticò, Lorenza ; Stazi, Maria Antonietta ; Brescianini, Sonia ; Lucatelli, Pierleone ; Boatta, Emanuele ; Zini, Chiara ; Fanelli, Fabrizio ; Baracchini, Claudio ; Meneghetti, Giorgio ; Osztovits, Janos ; Jermendy, Gyorgy ; Kiss, Robert Gabor ; Preda, Istvan ; Karlinger, Kinga ; Lannert, Agnes ; Molnar, Andrea Agnes ; Littvay, Levente ; Garami, Zsolt ; Berczi, Viktor ; Pucci, Giacomo ; Baffy, Gyorgy ; Schillaci, Giuseppe ; Pietiläinen, Kirsi H. / Association of body mass index with arterial stiffness and blood pressure components : A twin study. In: Atherosclerosis. 2013 ; Vol. 229, No. 2. pp. 388-395.

BibTeX

@article{b242fd12ffc14b56a1878f5c6b321358,
title = "Association of body mass index with arterial stiffness and blood pressure components: A twin study",
abstract = "Rationale: Obesity, blood pressure and arterial stiffness are heritable traits interconnected to each other but their possible common genetic and environmental etiologies are unknown. Methods: We studied 228 monozygotic and 150 dizygotic twin pairs aged 18-82 years from Italy, Hungary and the United States, of which 45 monozygotic and 38 dizygotic pairs were discordant for body mass index (BMI; intrapair difference (δ) in BMI≥3kg/m2). Blood pressure components and arterial stiffness were measured by TensioMed Arteriograph. Results: Hypertension was more prevalent among obese than non-obese individuals (55{\%} vs. 29{\%}, p<0.001). Age-, sex- and country-adjusted heritability estimates were high for hemodynamic measures (45{\%}-58{\%}) and BMI (78{\%}). According to bivariate Cholesky decomposition, phenotypic correlations between BMI and blood pressure components (r=-0.15 to 0.24, p<0.05) were largely explained by additive genetic factors (65{\%}-77{\%}) with the remaining explained by the unique environment. When controlling for genetic factors within all monozygotic pairs, δBMI was significantly correlated with δbrachial systolic blood pressure (SBP) and diastolic blood pressure (DBP), δmean arterial pressure, and δaortic SBP (r=0.15-0.17, p<0.05). For the same measures, heavier co-twins of BMI-discordant monozygotic pairs had significantly higher values than their leaner counterparts (p<0.05).",
keywords = "Augmentation index, Central blood pressure, Hypertension, Obesity, Pulse wave velocity, Twin study",
author = "Tarnoki, {Adam Domonkos} and Tarnoki, {David Laszlo} and Bogl, {Leonie H.} and Emanuela Medda and Corrado Fagnani and Lorenza Nistic{\`o} and Stazi, {Maria Antonietta} and Sonia Brescianini and Pierleone Lucatelli and Emanuele Boatta and Chiara Zini and Fabrizio Fanelli and Claudio Baracchini and Giorgio Meneghetti and Janos Osztovits and Gyorgy Jermendy and Kiss, {Robert Gabor} and Istvan Preda and Kinga Karlinger and Agnes Lannert and Molnar, {Andrea Agnes} and Levente Littvay and Zsolt Garami and Viktor Berczi and Giacomo Pucci and Gyorgy Baffy and Giuseppe Schillaci and Pietil{\"a}inen, {Kirsi H.}",
year = "2013",
month = "8",
day = "1",
doi = "10.1016/j.atherosclerosis.2013.05.001",
language = "English",
volume = "229",
pages = "388--395",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Association of body mass index with arterial stiffness and blood pressure components

T2 - Atherosclerosis

AU - Tarnoki, Adam Domonkos

AU - Tarnoki, David Laszlo

AU - Bogl, Leonie H.

AU - Medda, Emanuela

AU - Fagnani, Corrado

AU - Nisticò, Lorenza

AU - Stazi, Maria Antonietta

AU - Brescianini, Sonia

AU - Lucatelli, Pierleone

AU - Boatta, Emanuele

AU - Zini, Chiara

AU - Fanelli, Fabrizio

AU - Baracchini, Claudio

AU - Meneghetti, Giorgio

AU - Osztovits, Janos

AU - Jermendy, Gyorgy

AU - Kiss, Robert Gabor

AU - Preda, Istvan

AU - Karlinger, Kinga

AU - Lannert, Agnes

AU - Molnar, Andrea Agnes

AU - Littvay, Levente

AU - Garami, Zsolt

AU - Berczi, Viktor

AU - Pucci, Giacomo

AU - Baffy, Gyorgy

AU - Schillaci, Giuseppe

AU - Pietiläinen, Kirsi H.

PY - 2013/8/1

Y1 - 2013/8/1

N2 - Rationale: Obesity, blood pressure and arterial stiffness are heritable traits interconnected to each other but their possible common genetic and environmental etiologies are unknown. Methods: We studied 228 monozygotic and 150 dizygotic twin pairs aged 18-82 years from Italy, Hungary and the United States, of which 45 monozygotic and 38 dizygotic pairs were discordant for body mass index (BMI; intrapair difference (δ) in BMI≥3kg/m2). Blood pressure components and arterial stiffness were measured by TensioMed Arteriograph. Results: Hypertension was more prevalent among obese than non-obese individuals (55% vs. 29%, p<0.001). Age-, sex- and country-adjusted heritability estimates were high for hemodynamic measures (45%-58%) and BMI (78%). According to bivariate Cholesky decomposition, phenotypic correlations between BMI and blood pressure components (r=-0.15 to 0.24, p<0.05) were largely explained by additive genetic factors (65%-77%) with the remaining explained by the unique environment. When controlling for genetic factors within all monozygotic pairs, δBMI was significantly correlated with δbrachial systolic blood pressure (SBP) and diastolic blood pressure (DBP), δmean arterial pressure, and δaortic SBP (r=0.15-0.17, p<0.05). For the same measures, heavier co-twins of BMI-discordant monozygotic pairs had significantly higher values than their leaner counterparts (p<0.05).

AB - Rationale: Obesity, blood pressure and arterial stiffness are heritable traits interconnected to each other but their possible common genetic and environmental etiologies are unknown. Methods: We studied 228 monozygotic and 150 dizygotic twin pairs aged 18-82 years from Italy, Hungary and the United States, of which 45 monozygotic and 38 dizygotic pairs were discordant for body mass index (BMI; intrapair difference (δ) in BMI≥3kg/m2). Blood pressure components and arterial stiffness were measured by TensioMed Arteriograph. Results: Hypertension was more prevalent among obese than non-obese individuals (55% vs. 29%, p<0.001). Age-, sex- and country-adjusted heritability estimates were high for hemodynamic measures (45%-58%) and BMI (78%). According to bivariate Cholesky decomposition, phenotypic correlations between BMI and blood pressure components (r=-0.15 to 0.24, p<0.05) were largely explained by additive genetic factors (65%-77%) with the remaining explained by the unique environment. When controlling for genetic factors within all monozygotic pairs, δBMI was significantly correlated with δbrachial systolic blood pressure (SBP) and diastolic blood pressure (DBP), δmean arterial pressure, and δaortic SBP (r=0.15-0.17, p<0.05). For the same measures, heavier co-twins of BMI-discordant monozygotic pairs had significantly higher values than their leaner counterparts (p<0.05).

KW - Augmentation index

KW - Central blood pressure

KW - Hypertension

KW - Obesity

KW - Pulse wave velocity

KW - Twin study

UR - http://www.scopus.com/inward/record.url?scp=84880397147&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880397147&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2013.05.001

DO - 10.1016/j.atherosclerosis.2013.05.001

M3 - Article

VL - 229

SP - 388

EP - 395

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 2

ER -

ID: 2936443