TY - JOUR
T1 - Association of arsenic exposure with measles antibody titers in US children
T2 - Influence of sex and serum folate levels
AU - Roh, Taehyun
AU - Regan, Annette K.
AU - Johnson, Natalie M.
AU - Hasan, Nishat Tasnim
AU - Trisha, Nusrat Fahmida
AU - Aggarwal, Anisha
AU - Han, Daikwon
N1 - Funding Information:
This study was supported by the Texas A&M Triads for Transformation grant; and the US National Institute of Environmental Health Sciences grant P30ES029067 .
Publisher Copyright:
© 2023 The Authors
PY - 2024/1
Y1 - 2024/1
N2 - Exposure to arsenic during childhood is associated with various adverse health conditions. However, little is known about the effect of arsenic exposure on vaccine-related humoral immunity in children. We analyzed data from the National Health and Nutrition Examination Survey (2003–2004 and 2009–2010) to study the relationship between urinary arsenic and measles antibody levels in 476 US children aged 6–11. Multivariable linear regression was used to evaluate the association, adjusting for cycle, age, race, body mass index (BMI), serum cotinine, poverty index ratio, and vitamin B12 and selenium intakes. Stratified analyses were conducted by sex and serum folate levels using the median as cutoff (18.7 ng/mL). The measles antibody concentrations in the 3rd and 4th quartiles were found to have significantly decreased by 28.5 % (95 % Confidence Interval (CI) −47.6, −2.28) and 36.8 % (95 % CI −50.2, −19.5), compared to the lowest quartile among boys with serum folate levels lower than 18.7 ng/ml. The serum measles antibody titers significantly decreased by 16.7 % (95 %CI −25.0, −7.61) for each doubling of creatinine-corrected urinary total inorganic arsenic concentrations in the same group. No associations were found in boys with high serum folate levels or in girls. Further prospective studies are needed to validate these findings and develop interventions to protect children from infectious diseases.
AB - Exposure to arsenic during childhood is associated with various adverse health conditions. However, little is known about the effect of arsenic exposure on vaccine-related humoral immunity in children. We analyzed data from the National Health and Nutrition Examination Survey (2003–2004 and 2009–2010) to study the relationship between urinary arsenic and measles antibody levels in 476 US children aged 6–11. Multivariable linear regression was used to evaluate the association, adjusting for cycle, age, race, body mass index (BMI), serum cotinine, poverty index ratio, and vitamin B12 and selenium intakes. Stratified analyses were conducted by sex and serum folate levels using the median as cutoff (18.7 ng/mL). The measles antibody concentrations in the 3rd and 4th quartiles were found to have significantly decreased by 28.5 % (95 % Confidence Interval (CI) −47.6, −2.28) and 36.8 % (95 % CI −50.2, −19.5), compared to the lowest quartile among boys with serum folate levels lower than 18.7 ng/ml. The serum measles antibody titers significantly decreased by 16.7 % (95 %CI −25.0, −7.61) for each doubling of creatinine-corrected urinary total inorganic arsenic concentrations in the same group. No associations were found in boys with high serum folate levels or in girls. Further prospective studies are needed to validate these findings and develop interventions to protect children from infectious diseases.
KW - Arsenic
KW - Children
KW - Folate
KW - Measles
KW - Vaccine antibodies
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U2 - 10.1016/j.envint.2023.108329
DO - 10.1016/j.envint.2023.108329
M3 - Article
C2 - 38071850
AN - SCOPUS:85179468166
SN - 0160-4120
VL - 183
SP - 108329
JO - Environment International
JF - Environment International
M1 - 108329
ER -