TY - JOUR
T1 - Association of albuminuria with all-cause and cardiovascular disease mortality in diabetes
T2 - The Strong Heart Study
AU - Xu, Susan
AU - Lee, Elisa T.
AU - Best, Lyle G.
AU - Begum, Momotaz
AU - Knowler, William C.
AU - Fabsitz, Richard R.
AU - Howard, Barbara V.
PY - 2005/11/1
Y1 - 2005/11/1
N2 - Objectives - To estimate the relative risks of albuminuria with all-cause and cardiovascular disease (CVD) mortality in a large cohort of American Indians with diabetes. Methods - A total of 1,953 diabetic participants in the Strong Heart Study were evaluated based on albuminuria categories at baseline examination. The Cox proportional hazards model was used to examine associations. Results - Of the 1,953 participants, 605 (31%) and 410 (21%) had microalbuminuria and macroalbuminuria, respectively, at baseline examination. Microalbuminuria (HR=1.42, 95% Cl 1.15-1.77 for all-cause, and HR=1.48, Cl 1.01-2.17 for CVD), and macroalbuminuria (HR=3.39, Cl 2.71-4.25 for all-cause, and HR=3.74, Cl 2.56-5.47 for CVD) were significant predictors for all-cause and CVD mortality after adjustment for other CVD risk factors. Conclusions - Results from the present study suggest that albuminuria is a strong independent predictor of all-cause and CVD mortality in American Indians with diabetes.
AB - Objectives - To estimate the relative risks of albuminuria with all-cause and cardiovascular disease (CVD) mortality in a large cohort of American Indians with diabetes. Methods - A total of 1,953 diabetic participants in the Strong Heart Study were evaluated based on albuminuria categories at baseline examination. The Cox proportional hazards model was used to examine associations. Results - Of the 1,953 participants, 605 (31%) and 410 (21%) had microalbuminuria and macroalbuminuria, respectively, at baseline examination. Microalbuminuria (HR=1.42, 95% Cl 1.15-1.77 for all-cause, and HR=1.48, Cl 1.01-2.17 for CVD), and macroalbuminuria (HR=3.39, Cl 2.71-4.25 for all-cause, and HR=3.74, Cl 2.56-5.47 for CVD) were significant predictors for all-cause and CVD mortality after adjustment for other CVD risk factors. Conclusions - Results from the present study suggest that albuminuria is a strong independent predictor of all-cause and CVD mortality in American Indians with diabetes.
KW - Albuminuria
KW - American Indians
KW - Association
KW - Cardiovascular disease mortality
KW - Diabetes
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U2 - 10.1177/14746514050050060701
DO - 10.1177/14746514050050060701
M3 - Article
AN - SCOPUS:30544433688
SN - 1474-6514
VL - 5
SP - 334
EP - 340
JO - British Journal of Diabetes and Vascular Disease
JF - British Journal of Diabetes and Vascular Disease
IS - 6
ER -