Association of albuminuria with all-cause and cardiovascular disease mortality in diabetes: The Strong Heart Study

Susan Xu, Elisa T. Lee, Lyle G. Best, Momotaz Begum, William C. Knowler, Richard R. Fabsitz, Barbara V. Howard

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Objectives - To estimate the relative risks of albuminuria with all-cause and cardiovascular disease (CVD) mortality in a large cohort of American Indians with diabetes. Methods - A total of 1,953 diabetic participants in the Strong Heart Study were evaluated based on albuminuria categories at baseline examination. The Cox proportional hazards model was used to examine associations. Results - Of the 1,953 participants, 605 (31%) and 410 (21%) had microalbuminuria and macroalbuminuria, respectively, at baseline examination. Microalbuminuria (HR=1.42, 95% Cl 1.15-1.77 for all-cause, and HR=1.48, Cl 1.01-2.17 for CVD), and macroalbuminuria (HR=3.39, Cl 2.71-4.25 for all-cause, and HR=3.74, Cl 2.56-5.47 for CVD) were significant predictors for all-cause and CVD mortality after adjustment for other CVD risk factors. Conclusions - Results from the present study suggest that albuminuria is a strong independent predictor of all-cause and CVD mortality in American Indians with diabetes.

Original languageEnglish (US)
Pages (from-to)334-340
Number of pages7
JournalBritish Journal of Diabetes and Vascular Disease
Volume5
Issue number6
DOIs
StatePublished - Nov 1 2005

Keywords

  • Albuminuria
  • American Indians
  • Association
  • Cardiovascular disease mortality
  • Diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism

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