Association between VDR ApaI polymorphism and hip bone mineral density can be modified by body mass index: A study on postmenopausal Chinese women

Hong Xu, Dong Hai Xiong, Fu Hua Xu, Yuan Yuan Zhang, Shu Feng Lei, Hong Wen Deng

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Osteoporosis is a major public health problem for old people. Genetic factors are considered to be major contributors to the pathogenesis of postmenopausal osteoporosis. The vitamin D receptor (VDR) gene is a prominent candidate gene for the regulation of postmenopausal bone mass; however, despite extensive studies, controversy remains regarding its association with postmenopausal body mineral density (BMD) variation. In this study, a total of 260 healthy postmenopausal Chinese women were genotyped at the VDR ApaI locus using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). Raw hip BMD was significantly associated with VDR ApaI polymorphism with and without adjusting for age (P=0.015 and 0.040, respectively). This genetic effect can explain 3.32% of hip BMD variation. However, the significant association vanished after correcting for both age and body mass index (BMI) (P=0.169). In addition, we observed a significant association between VDR ApaI polymorphism with unadjusted I (P=0.042) or BMI adjusted for age (P=0.049). The raw hip BMD was also found to be significantly correlated with BMI (r=0.517, P=0.0001), with BMI explaining 26.35% of the variation of hip BMD. All of these facts prompt us to conclude that the significant association between the VDR ApaI genotype and hip BMD may be modified by BMI in postmenopausal Chinese women. Our findings may partially explain the earlier inconsistent association results concerning the VDR gene and BMD, and highlight the importance of incorporating covariates such as BMI into osteoporosis association studies.

Original languageEnglish (US)
Pages (from-to)61-67
Number of pages7
JournalActa Biochimica et Biophysica Sinica
Volume37
Issue number1
DOIs
StatePublished - Jan 2005

Keywords

  • Body mass index (BMI)
  • Bone mineral density (BMD)
  • Genetic association
  • Osteoporosis
  • Vitamin D receptor (VDR) gene

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

Fingerprint

Dive into the research topics of 'Association between VDR ApaI polymorphism and hip bone mineral density can be modified by body mass index: A study on postmenopausal Chinese women'. Together they form a unique fingerprint.

Cite this