TY - JOUR
T1 - Association Between Plasma Apolipoprotein M With Alzheimer’s Disease
T2 - A Cross-Sectional Pilot Study From China
AU - Xin, Jia Yan
AU - Huang, Xiao
AU - Sun, Ying
AU - Jiang, Hai Song
AU - Fan, Jin
AU - Yu, Neng Wei
AU - Guo, Fu Qiang
AU - Ye, Fang
AU - Xiao, Jun
AU - Le, Wei Dong
AU - Yang, Shao Jie
AU - Xiang, Yang
N1 - Publisher Copyright:
Copyright © 2022 Xin, Huang, Sun, Jiang, Fan, Yu, Guo, Ye, Xiao, Le, Yang and Xiang.
PY - 2022/3/18
Y1 - 2022/3/18
N2 - BACKGROUND: Recent evidence of genetics and metabonomics indicated a potential role of apolipoprotein M (ApoM) in the pathogenesis of Alzheimer's disease (AD). Here, we aimed to investigate the association between plasma ApoM with AD.METHODS: A multicenter, cross-sectional study recruited patients with AD (
n = 67), age- and sex-matched cognitively normal (CN) controls (
n = 73). After the data collection of demographic characteristics, lifestyle risk factors, and medical history, we examined and compared the plasma levels of ApoM, tau phosphorylated at threonine 217 (p-tau217) and neurofilament light (NfL). Multivariate logistic regression analysis was applied to determine the association of plasma ApoM with the presence of AD. The correlation analysis was used to explore the correlations between plasma ApoM with cognitive function [Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA)], activities of daily living (ADL), and the representative blood-based biomarkers (plasma p-tau217 and NfL). Receiver operating characteristic (ROC) analysis and Delong's test were used to determine the diagnostic power of plasma ApoM.
RESULTS: Plasma ApoM and its derived indicators (ratios of ApoM/TC, ApoM/TG, ApoM/HDL-C, and ApoM/LDL-C) were significantly higher in AD group than those in CN group (each
p < 0.0001). After adjusted for the risk factors of AD, the plasma ApoM and its derived indicators were significantly associated with the presence of AD, respectively. ApoM (OR = 1.058, 95% CI: 1.027-1.090,
p < 0.0001), ApoM/TC ratio (OR = 1.239, 95% CI: 1.120-1.372,
p < 0.0001), ApoM/TG ratio (OR = 1.064, 95% CI: 1.035-1.095,
p < 0.0001), ApoM/HDL-C ratio (OR = 1.069, 95% CI: 1.037-1.102,
p < 0.0001), and ApoM/LDL-C ratio (OR = 1.064, 95% CI:1.023-1.106,
p = 0.002). In total participants, plasma ApoM was significantly positively correlated with plasma p-tau217, plasma NfL, and ADL (each
p < 0.0001) and significantly negatively correlated with MMSE and MoCA (each
p < 0.0001), respectively. In further subgroup analyses, these associations remained in different
APOEϵ 4 status participants and sex subgroups. ApoM/TC ratio (ΔAUC = 0.056,
p = 0.044) and ApoM/TG ratio (ΔAUC = 0.097,
p = 0.011) had a statistically remarkably larger AUC than ApoM, respectively. The independent addition of ApoM and its derived indicators to the basic model [combining age, sex,
APOEϵ 4, and body mass index (BMI)] led to the significant improvement in diagnostic power, respectively (each
p < 0.05).
CONCLUSION: All the findings preliminarily uncovered the association between plasma ApoM and AD and provided more evidence of the potential of ApoM as a candidate biomarker of AD.
AB - BACKGROUND: Recent evidence of genetics and metabonomics indicated a potential role of apolipoprotein M (ApoM) in the pathogenesis of Alzheimer's disease (AD). Here, we aimed to investigate the association between plasma ApoM with AD.METHODS: A multicenter, cross-sectional study recruited patients with AD (
n = 67), age- and sex-matched cognitively normal (CN) controls (
n = 73). After the data collection of demographic characteristics, lifestyle risk factors, and medical history, we examined and compared the plasma levels of ApoM, tau phosphorylated at threonine 217 (p-tau217) and neurofilament light (NfL). Multivariate logistic regression analysis was applied to determine the association of plasma ApoM with the presence of AD. The correlation analysis was used to explore the correlations between plasma ApoM with cognitive function [Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA)], activities of daily living (ADL), and the representative blood-based biomarkers (plasma p-tau217 and NfL). Receiver operating characteristic (ROC) analysis and Delong's test were used to determine the diagnostic power of plasma ApoM.
RESULTS: Plasma ApoM and its derived indicators (ratios of ApoM/TC, ApoM/TG, ApoM/HDL-C, and ApoM/LDL-C) were significantly higher in AD group than those in CN group (each
p < 0.0001). After adjusted for the risk factors of AD, the plasma ApoM and its derived indicators were significantly associated with the presence of AD, respectively. ApoM (OR = 1.058, 95% CI: 1.027-1.090,
p < 0.0001), ApoM/TC ratio (OR = 1.239, 95% CI: 1.120-1.372,
p < 0.0001), ApoM/TG ratio (OR = 1.064, 95% CI: 1.035-1.095,
p < 0.0001), ApoM/HDL-C ratio (OR = 1.069, 95% CI: 1.037-1.102,
p < 0.0001), and ApoM/LDL-C ratio (OR = 1.064, 95% CI:1.023-1.106,
p = 0.002). In total participants, plasma ApoM was significantly positively correlated with plasma p-tau217, plasma NfL, and ADL (each
p < 0.0001) and significantly negatively correlated with MMSE and MoCA (each
p < 0.0001), respectively. In further subgroup analyses, these associations remained in different
APOEϵ 4 status participants and sex subgroups. ApoM/TC ratio (ΔAUC = 0.056,
p = 0.044) and ApoM/TG ratio (ΔAUC = 0.097,
p = 0.011) had a statistically remarkably larger AUC than ApoM, respectively. The independent addition of ApoM and its derived indicators to the basic model [combining age, sex,
APOEϵ 4, and body mass index (BMI)] led to the significant improvement in diagnostic power, respectively (each
p < 0.05).
CONCLUSION: All the findings preliminarily uncovered the association between plasma ApoM and AD and provided more evidence of the potential of ApoM as a candidate biomarker of AD.
KW - Alzheimer’s disease
KW - apolipoprotein M
KW - biomarker
KW - neurofilament light chain
KW - tau
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U2 - 10.3389/fnagi.2022.838223
DO - 10.3389/fnagi.2022.838223
M3 - Article
C2 - 35370599
AN - SCOPUS:85127943391
SN - 1663-4365
VL - 14
SP - 838223
JO - Frontiers in Aging Neuroscience
JF - Frontiers in Aging Neuroscience
M1 - 838223
ER -