Association between hematological indices and coronary calcification in symptomatic patients without history of coronary artery disease

Kongkiat Chaikriangkrai, Mahwash Kassi, Sama Alchalabi, Sayf Khaleel Bala, Rosalyn Adigun, Sharleen Botero, Su Min Chang

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background: Atherosclerotic coronary artery disease (CAD) has long been shown to involve chronic low-grade subclinical inflammation. However, whether there is association between hematological indices assessed by complete blood count (CBC) and coronary atherosclerotic burden has not been well studied. Materials and Methods: Consecutive 868 patients without known CAD who presented with acute chest pain to emergency department and underwent coronary artery calcium (CAC) scoring evaluation by multi-detector cardiac computed tomography were included in our study. Clinical characteristics and CBC indices were compared among different CAC groups. Results: The cohort comprised 60% male with a mean age of 61 (SD = 14) years. Median Framingham risk of CAD was 4% (range 1-16%). Median CAC score was 0 (IQR 0-43). Higher CAC groups had significantly higher Framingham risk of CAD than lower CAC groups (P < 0.001). Among different CAC categories, there was no statistically significant difference in hemoglobin level (p 0.45), mean corpuscular volume (p 0.43), mean corpuscular hemoglobin (p 0.28), mean corpuscular hemoglobin volume (p 0.36), red cell distribution width (0.42), total white blood cell counts (p 0.291), neutrophil counts (p 0.352), lymphocyte counts (p 0.92), neutrophil to lymphocyte ratio (p 0.68), monocyte count (p 0.48), and platelet counts (p 0.25). Conclusion: Our study did not detect significant association between hematological indices assessed with CBC and coronary calcification in symptomatic patients without known CAD.

Original languageEnglish (US)
Pages (from-to)433-439
Number of pages7
JournalNorth American Journal of Medical Sciences
Volume6
Issue number9
DOIs
StatePublished - Sep 1 2014

Keywords

  • Coronary artery disease
  • Inflammation
  • Neutrophil-to-lymphocyte ratio
  • Red cell distribution width
  • White blood cell

ASJC Scopus subject areas

  • Medicine(all)

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