Association between H63D polymorphism and alcoholic liver disease risk: A meta-analysis

Yizhen Fang, Huayue Lin, Jingkun Wang, Xiaosong Su, Fen Wang, Pan You, Jianjun Niu, Zhongying Zhang

Research output: Contribution to journalReview article

Abstract

Objectives: Gene plays an important role in alcoholic liver disease (ALD). The H63D polymorphism (rs1799945, C>G) of hemochromatosis (HFE) gene has been found to be related to alcoholic liver disease in various studies. To classify the association between H63D polymorphism and alcoholic liver disease susceptibility, we performed a meta-analysis. Methods: We retrieved published studies on the association between H63D and ALD by electronic database (Embase, PubMed, Cochrane and Web of Science). Related data was extracted. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were performed with fixed effect model or random effect model. Sensitivity analysis and Publication bias have also been presented. Results: Nine eligible studies were included, with a total of 2720 controls and 1200 cases. The pooled results showed that a significantly increased risk of ALD susceptibility was observed in homozygote model (GG versus CC: OR=2.28, 95% CI 1.39-3.75, I2=0%, PH=0.999) and recessive model (GG versus GC+CC: OR=2.22, 95% CI 1.35-3.65, I2=0%, PH=0.999). Ethnic subgroup analysis showed similar results in Caucasian: homozygote model (GG versus CC: OR=2.28, 95% CI 1.39-3.75, I2=0%, PH=0.999), recessive model (GG versus GC+CC: OR=2.22, 95% CI 1.35-3.65, I2=0%, PH=0.999). In the subgroup analysis by genotyping method and quality, the effects remained in high quality studies and PCR-RFLP (restriction fragment length polymorphism). Conclusions: This meta-analysis suggested that H63D polymorphism (rs1799945) is associated with ALD susceptibility, especially for GG genotype in Caucasian. H63D polymorphism of HFE gene may be a potential target in gene therapy for alcoholic liver disease patients.

Original languageEnglish (US)
Article numberIJCEM0039448
Pages (from-to)69-78
Number of pages10
JournalInternational Journal of Clinical and Experimental Medicine
Volume10
Issue number1
StatePublished - Jan 30 2017

Keywords

  • Alcoholic
  • Liver diseases
  • Membrane proteins
  • Meta-analysis
  • Polymorphism

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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