TY - JOUR
T1 - Association between genital tract cytomegalovirus infection and bacterial vaginosis
AU - Ross, Shannon A.
AU - Novak, Zdenek
AU - Ashrith, Guha
AU - Rivera, Lisa B.
AU - Britt, William J.
AU - Hedges, Spencer
AU - Schwebke, Jane R.
AU - Boppana, Suresh
N1 - Funding Information:
Received 22 March 2005; accepted 6 June 2005; electronically published 7 October 2005. Presented in part: 42nd annual meeting of the Infectious Diseases Society of America, Boston, 2 October 2004 (abstract 819). Potential conflicts of interest: J.R.S. receives honoraria from 3M Corporation, which supplied the study drug for the study from which our subjects were recruited. Financial support: National Institute on Deafness and Other Communication Disorders (grant R01 DC04163 to S.B.); National Institutes of Health (NIH) Sexually Transmitted Disease Cooperative Research Centers (grant 5U19AI038514-09 to J.R.S.); NIH (grant 1 T32 AI052069 to S.A.R.). Reprints or correspondence: Dr. Shannon A. Ross, University of Alabama at Birmingham, Children’s Hospital, CHB 304, 1600 7th Ave. S., Birmingham, AL 35233 ([email protected]).
PY - 2005/11/15
Y1 - 2005/11/15
N2 - Women with sexually transmitted diseases (STDs) and bacterial vaginosis (BV) have increased rates of cytomegalovirus (CMV) seroprevalence and CMV seroconversion. To characterize the association between genital tract CMV infection and BV, vaginal wash specimens from 52 women attending an STD clinic were analyzed. Significantly more women with BV shed CMV in the lower genital tract than did women without BV. In addition, most of the women who were shedding CMV were infected with >1 virus strain. These results suggest that local CMV replication and infection with multiple CMV strains is facilitated by the presence of BV.
AB - Women with sexually transmitted diseases (STDs) and bacterial vaginosis (BV) have increased rates of cytomegalovirus (CMV) seroprevalence and CMV seroconversion. To characterize the association between genital tract CMV infection and BV, vaginal wash specimens from 52 women attending an STD clinic were analyzed. Significantly more women with BV shed CMV in the lower genital tract than did women without BV. In addition, most of the women who were shedding CMV were infected with >1 virus strain. These results suggest that local CMV replication and infection with multiple CMV strains is facilitated by the presence of BV.
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U2 - 10.1086/497150
DO - 10.1086/497150
M3 - Article
C2 - 16235170
AN - SCOPUS:27744565990
SN - 0022-1899
VL - 192
SP - 1727
EP - 1730
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 10
ER -