Association between genital tract cytomegalovirus infection and bacterial vaginosis

Shannon A. Ross; Zdenek Novak; Guha Ashrith; Lisa B. Rivera; William J. Britt; Spencer Hedges; Jane R. Schwebke; Suresh Boppana

doi:10.1086/497150

Association between genital tract cytomegalovirus infection and bacterial vaginosis

Shannon A. Ross, Zdenek Novak, Guha Ashrith, Lisa B. Rivera, William J. Britt, Spencer Hedges, Jane R. Schwebke, Suresh Boppana

Research output: Contribution to journal › Article

28 Scopus citations

Abstract

Women with sexually transmitted diseases (STDs) and bacterial vaginosis (BV) have increased rates of cytomegalovirus (CMV) seroprevalence and CMV seroconversion. To characterize the association between genital tract CMV infection and BV, vaginal wash specimens from 52 women attending an STD clinic were analyzed. Significantly more women with BV shed CMV in the lower genital tract than did women without BV. In addition, most of the women who were shedding CMV were infected with >1 virus strain. These results suggest that local CMV replication and infection with multiple CMV strains is facilitated by the presence of BV.

Original language	English (US)
Pages (from-to)	1727-1730
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	192
Issue number	10
DOIs	https://doi.org/10.1086/497150
State	Published - Nov 15 2005

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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10.1086/497150

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title = "Association between genital tract cytomegalovirus infection and bacterial vaginosis",

abstract = "Women with sexually transmitted diseases (STDs) and bacterial vaginosis (BV) have increased rates of cytomegalovirus (CMV) seroprevalence and CMV seroconversion. To characterize the association between genital tract CMV infection and BV, vaginal wash specimens from 52 women attending an STD clinic were analyzed. Significantly more women with BV shed CMV in the lower genital tract than did women without BV. In addition, most of the women who were shedding CMV were infected with >1 virus strain. These results suggest that local CMV replication and infection with multiple CMV strains is facilitated by the presence of BV.",

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AU - Ross, Shannon A.

AU - Novak, Zdenek

AU - Ashrith, Guha

AU - Rivera, Lisa B.

AU - Britt, William J.

AU - Hedges, Spencer

AU - Schwebke, Jane R.

AU - Boppana, Suresh

PY - 2005/11/15

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N2 - Women with sexually transmitted diseases (STDs) and bacterial vaginosis (BV) have increased rates of cytomegalovirus (CMV) seroprevalence and CMV seroconversion. To characterize the association between genital tract CMV infection and BV, vaginal wash specimens from 52 women attending an STD clinic were analyzed. Significantly more women with BV shed CMV in the lower genital tract than did women without BV. In addition, most of the women who were shedding CMV were infected with >1 virus strain. These results suggest that local CMV replication and infection with multiple CMV strains is facilitated by the presence of BV.

AB - Women with sexually transmitted diseases (STDs) and bacterial vaginosis (BV) have increased rates of cytomegalovirus (CMV) seroprevalence and CMV seroconversion. To characterize the association between genital tract CMV infection and BV, vaginal wash specimens from 52 women attending an STD clinic were analyzed. Significantly more women with BV shed CMV in the lower genital tract than did women without BV. In addition, most of the women who were shedding CMV were infected with >1 virus strain. These results suggest that local CMV replication and infection with multiple CMV strains is facilitated by the presence of BV.

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