Association between FFRCT and instantaneous wave-free ratio (iFR) of intermediate lesions on coronary computed tomography angiography

Research output: Contribution to journalArticlepeer-review

Abstract

Background: New data suggests long term outcomes of coronary revascularization based on instantaneous wave free ratio (iFR) are equivalent to invasive fractional flow reserve (FFR). We aimed to evaluate the correlation between non-invasive FFR derived from cardiac CT (FFRCT) and iFR. Methods: Data from 21 patients with 26 vessels, who underwent both FFRCT computation and invasive iFR measurement, were analysed. We evaluated diagnostic performance of FFRCT according to two cut-off values of ≤0.80 and ≤0.70 with iFR ≤0.89 as the reference standard. Results: In a per vessel analysis, the average diameter stenosis was 59%, mean FFRCT was 0.81 while mean iFR was 0.90. Using an FFRCT cut-off of 0.80, the sensitivity, specificity, positive predictive value, negative predictive value and overall accuracy for FFRCT were 86%, 84%, 67%, 94%, and 85% respectively. When the cut-off was lowered to 0.70, the sensitivity, specificity, positive predictive value, negative predictive value and overall accuracy for FFRCT were 57%, 100%, 100%, 86% and 88% respectively. Conclusion: FFRCT correlates well with iFR in this small retrospective study. Larger studies are required to confirm this finding.

Original languageEnglish (US)
JournalCardiovascular Revascularization Medicine
DOIs
StateAccepted/In press - 2020

Keywords

  • CT-FFR
  • Coronary CT angiography
  • Coronary flow reserve
  • Fractional flow reserve
  • Instantaneous wave-free ratio

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'Association between FFR<sub>CT</sub> and instantaneous wave-free ratio (iFR) of intermediate lesions on coronary computed tomography angiography'. Together they form a unique fingerprint.

Cite this