Association between cardiovascular risk profiles and the presence and extent of different types of coronary atherosclerotic plaque as detected by multidetector computed tomography

Fabian Bamberg, Nina Dannemann, Michael D. Shapiro, Sujith K. Seneviratne, Maros Ferencik, Javed Butler, Wolfgang Koenig, Khurram Nasir, Ricardo C. Cury, Ahmed Tawakol, Stephan Achenbach, Thomas J. Brady, Udo Hoffmann

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

Objective: To assess the association between cardiovascular risk factors and extent of noncalcified- (NCAP), mixed-(MCAP), and calcified coronary atherosclerotic plaque (CAP). Methods and Results: In this cross-sectional study, we included consecutive subjects who presented with chest pain but had no history of coronary artery disease (CAD) and did not develop acute coronary syndrome. Contrast-enhanced 64-slice coronary MDCT was performed to determine the presence of NCAP, MCAP, and CAP for each coronary segment. Among 195 patients (91 women, mean age: 54.6±12.0) exclusively NCAP was detected in 11 patients (5.6%). The extent of NCAP decreased and the extent of MCAP and CAP increased with age (P=0.06, P=0.02, and P=0.13, respectively). Hyperlipidemia and family history of CAD were associated with the extent of NCAP after adjusting for other risk factors (P=0.02 and P=0.04, respectively) or for the extent of MCAP and CAP (P=0.02 and P=0.05, respectively). Conclusion: Our data suggest that only a small proportion of individuals have exclusively NCAP and indicate that the relation of NCAP and CAP changes with age. Among individual risk factors, hyperlipidemia and family history of CAD may be associated with the extent of NCAP. Larger observational trials are necessary to confirm our findings.

Original languageEnglish (US)
Pages (from-to)568-574
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume28
Issue number3
DOIs
StatePublished - Mar 1 2008

Keywords

  • Atherosclerosis
  • Imaging
  • Tomography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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