Association between acute respiratory disease events and the MUC5B promoter polymorphism in smokers

Samuel Y. Ash; Rola Harmouche; Rachel K. Putman; James C. Ross; Fernando J. Martinez; Augustine M. Choi; Russell P. Bowler; Elizabeth A. Regan; Jeffrey L. Curtis; Meilan K. Han; Richard C. Boucher; Wanda K. O'Neal; Hiroto Hatabu; David A. Lynch; Ivan O. Rosas; Gary M. Hunninghake; Raul San Jose Estepar; George R. Washko

doi:10.1136/thoraxjnl-2017-211208

Association between acute respiratory disease events and the MUC5B promoter polymorphism in smokers

Samuel Y. Ash, Rola Harmouche, Rachel K. Putman, James C. Ross, Fernando J. Martinez, Augustine M. Choi, Russell P. Bowler, Elizabeth A. Regan, Jeffrey L. Curtis, Meilan K. Han, Richard C. Boucher, Wanda K. O'Neal, Hiroto Hatabu, David A. Lynch, Ivan O. Rosas, Gary M. Hunninghake, Raul San Jose Estepar, George R. Washko

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A single-nucleotide polymorphism (rs35705950) in the mucin 5B (MUC5B) gene promoter is associated with pulmonary fibrosis and interstitial features on chest CT but may also have beneficial effects. In non-Hispanic whites in the COPDGene cohort with interstitial features (n=454), the MUC5B promoter polymorphism was associated with a 61% lower odds of a prospectively reported acute respiratory disease event (P=0.001), a longer time-to-first event (HR=0.57; P=0.006) and 40% fewer events (P=0.016). The MUC5B promoter polymorphism may have a beneficial effect on the risk of acute respiratory disease events in smokers with interstitial CT features.

Original language	English (US)
Pages (from-to)	1071-1074
Number of pages	4
Journal	Thorax
Volume	73
Issue number	11
DOIs	https://doi.org/10.1136/thoraxjnl-2017-211208
State	Published - Nov 1 2018

Keywords

copd exacerbations
idiopathic pulmonary fibrosis
interstitial fibrosis

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1136/thoraxjnl-2017-211208

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Ash, S. Y., Harmouche, R., Putman, R. K., Ross, J. C., Martinez, F. J., Choi, A. M., Bowler, R. P., Regan, E. A., Curtis, J. L., Han, M. K., Boucher, R. C., O'Neal, W. K., Hatabu, H., Lynch, D. A., Rosas, I. O., Hunninghake, G. M., San Jose Estepar, R., & Washko, G. R. (2018). Association between acute respiratory disease events and the MUC5B promoter polymorphism in smokers. Thorax, 73(11), 1071-1074. https://doi.org/10.1136/thoraxjnl-2017-211208

Ash, SY, Harmouche, R, Putman, RK, Ross, JC, Martinez, FJ, Choi, AM, Bowler, RP, Regan, EA, Curtis, JL, Han, MK, Boucher, RC, O'Neal, WK, Hatabu, H, Lynch, DA, Rosas, IO, Hunninghake, GM, San Jose Estepar, R & Washko, GR 2018, 'Association between acute respiratory disease events and the MUC5B promoter polymorphism in smokers', Thorax, vol. 73, no. 11, pp. 1071-1074. https://doi.org/10.1136/thoraxjnl-2017-211208

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title = "Association between acute respiratory disease events and the MUC5B promoter polymorphism in smokers",

abstract = "A single-nucleotide polymorphism (rs35705950) in the mucin 5B (MUC5B) gene promoter is associated with pulmonary fibrosis and interstitial features on chest CT but may also have beneficial effects. In non-Hispanic whites in the COPDGene cohort with interstitial features (n=454), the MUC5B promoter polymorphism was associated with a 61\% lower odds of a prospectively reported acute respiratory disease event (P=0.001), a longer time-to-first event (HR=0.57; P=0.006) and 40\% fewer events (P=0.016). The MUC5B promoter polymorphism may have a beneficial effect on the risk of acute respiratory disease events in smokers with interstitial CT features.",

keywords = "copd exacerbations, idiopathic pulmonary fibrosis, interstitial fibrosis",

author = "Ash, \{Samuel Y.\} and Rola Harmouche and Putman, \{Rachel K.\} and Ross, \{James C.\} and Martinez, \{Fernando J.\} and Choi, \{Augustine M.\} and Bowler, \{Russell P.\} and Regan, \{Elizabeth A.\} and Curtis, \{Jeffrey L.\} and Han, \{Meilan K.\} and Boucher, \{Richard C.\} and O'Neal, \{Wanda K.\} and Hiroto Hatabu and Lynch, \{David A.\} and Rosas, \{Ivan O.\} and Hunninghake, \{Gary M.\} and \{San Jose Estepar\}, Raul and Washko, \{George R.\}",

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doi = "10.1136/thoraxjnl-2017-211208",

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AU - Ash, Samuel Y.

AU - Harmouche, Rola

AU - Putman, Rachel K.

AU - Ross, James C.

AU - Martinez, Fernando J.

AU - Choi, Augustine M.

AU - Bowler, Russell P.

AU - Regan, Elizabeth A.

AU - Curtis, Jeffrey L.

AU - Han, Meilan K.

AU - Boucher, Richard C.

AU - O'Neal, Wanda K.

AU - Hatabu, Hiroto

AU - Lynch, David A.

AU - Rosas, Ivan O.

AU - Hunninghake, Gary M.

AU - San Jose Estepar, Raul

AU - Washko, George R.

PY - 2018/11/1

Y1 - 2018/11/1

N2 - A single-nucleotide polymorphism (rs35705950) in the mucin 5B (MUC5B) gene promoter is associated with pulmonary fibrosis and interstitial features on chest CT but may also have beneficial effects. In non-Hispanic whites in the COPDGene cohort with interstitial features (n=454), the MUC5B promoter polymorphism was associated with a 61% lower odds of a prospectively reported acute respiratory disease event (P=0.001), a longer time-to-first event (HR=0.57; P=0.006) and 40% fewer events (P=0.016). The MUC5B promoter polymorphism may have a beneficial effect on the risk of acute respiratory disease events in smokers with interstitial CT features.

AB - A single-nucleotide polymorphism (rs35705950) in the mucin 5B (MUC5B) gene promoter is associated with pulmonary fibrosis and interstitial features on chest CT but may also have beneficial effects. In non-Hispanic whites in the COPDGene cohort with interstitial features (n=454), the MUC5B promoter polymorphism was associated with a 61% lower odds of a prospectively reported acute respiratory disease event (P=0.001), a longer time-to-first event (HR=0.57; P=0.006) and 40% fewer events (P=0.016). The MUC5B promoter polymorphism may have a beneficial effect on the risk of acute respiratory disease events in smokers with interstitial CT features.

KW - copd exacerbations

KW - idiopathic pulmonary fibrosis

KW - interstitial fibrosis

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EP - 1074

JO - Thorax

JF - Thorax

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ER -

Association between acute respiratory disease events and the MUC5B promoter polymorphism in smokers

Abstract

Keywords

ASJC Scopus subject areas

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