Association between acute respiratory disease events and the MUC5B promoter polymorphism in smokers

Samuel Y. Ash, Rola Harmouche, Rachel K. Putman, James C. Ross, Fernando J. Martinez, Augustine M. Choi, Russell P. Bowler, Elizabeth A. Regan, Jeffrey L. Curtis, Meilan K. Han, Richard C. Boucher, Wanda K. O'Neal, Hiroto Hatabu, David A. Lynch, Ivan O. Rosas, Gary M. Hunninghake, Raul San Jose Estepar, George R. Washko

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

A single-nucleotide polymorphism (rs35705950) in the mucin 5B (MUC5B) gene promoter is associated with pulmonary fibrosis and interstitial features on chest CT but may also have beneficial effects. In non-Hispanic whites in the COPDGene cohort with interstitial features (n=454), the MUC5B promoter polymorphism was associated with a 61% lower odds of a prospectively reported acute respiratory disease event (P=0.001), a longer time-to-first event (HR=0.57; P=0.006) and 40% fewer events (P=0.016). The MUC5B promoter polymorphism may have a beneficial effect on the risk of acute respiratory disease events in smokers with interstitial CT features.

Original languageEnglish (US)
JournalThorax
DOIs
StateAccepted/In press - Feb 13 2018

Keywords

  • copd exacerbations
  • idiopathic pulmonary fibrosis
  • interstitial fibrosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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