Assignment of the erythropoietin receptor (EPOR) gene to mouse chromosome 9 and human chromosome 19

M. Budarf, K. Huebner, B. Emanuel, C. M. Croce, Neal G. Copeland, Nancy A. Jenkins, A. D. D'Andrea

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Erythropoietin (EPO), the primary regulator of mammalian erythropoiesis, binds and activates a specific receptor on erythroid progenitors. The human and mouse cDNAs for this receptor (EPOR) have recently been isolated. These cDNAs were used to establish the genomic location of the EPOR gene. By somatic cell hybrid analysis, the locus for the EPOR maps to human chromosome (Chr) 19pter-q12. By interspecific backcross mapping the locus is tightly linked to the murine Ldlr locus near the centromere of mouse Chr 9. This region of mouse Chr 9 is homologous to a region of human Chr 19p13 carrying the human LDLR and MEL loci, strongly suggesting that the human EPOR gene is at 19p13 near the human LDLR locus.

Original languageEnglish (US)
Pages (from-to)575-578
Number of pages4
JournalGenomics
Volume8
Issue number3
DOIs
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Genetics

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