Assignment of the erythropoietin receptor (EPOR) gene to mouse chromosome 9 and human chromosome 19

M. Budarf; K. Huebner; B. Emanuel; C. M. Croce; N. G. Copeland; N. A. Jenkins; A. D. D'Andrea

doi:10.1016/0888-7543(90)90047-X

Assignment of the erythropoietin receptor (EPOR) gene to mouse chromosome 9 and human chromosome 19

M. Budarf, K. Huebner, B. Emanuel, C. M. Croce, N. G. Copeland, N. A. Jenkins, A. D. D'Andrea

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Abstract

Erythropoietin (EPO), the primary regulator of mammalian erythropoiesis, binds and activates a specific receptor on erythroid progenitors. The human and mouse cDNAs for this receptor (EPOR) have recently been isolated. These cDNAs were used to establish the genomic location of the EPOR gene. By somatic cell hybrid analysis, the locus for the EPOR maps to human chromosome (Chr) 19pter-q12. By interspecific backcross mapping the locus is tightly linked to the murine Ldlr locus near the centromere of mouse Chr 9. This region of mouse Chr 9 is homologous to a region of human Chr 19p13 carrying the human LDLR and MEL loci, strongly suggesting that the human EPOR gene is at 19p13 near the human LDLR locus.

Original language	English (US)
Pages (from-to)	575-578
Number of pages	4
Journal	Genomics
Volume	8
Issue number	3
DOIs	https://doi.org/10.1016/0888-7543(90)90047-X
State	Published - Nov 1990

ASJC Scopus subject areas

Genetics

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10.1016/0888-7543(90)90047-X

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@article{60258014c32142e7a39fe0f0190df518,

title = "Assignment of the erythropoietin receptor (EPOR) gene to mouse chromosome 9 and human chromosome 19",

abstract = "Erythropoietin (EPO), the primary regulator of mammalian erythropoiesis, binds and activates a specific receptor on erythroid progenitors. The human and mouse cDNAs for this receptor (EPOR) have recently been isolated. These cDNAs were used to establish the genomic location of the EPOR gene. By somatic cell hybrid analysis, the locus for the EPOR maps to human chromosome (Chr) 19pter-q12. By interspecific backcross mapping the locus is tightly linked to the murine Ldlr locus near the centromere of mouse Chr 9. This region of mouse Chr 9 is homologous to a region of human Chr 19p13 carrying the human LDLR and MEL loci, strongly suggesting that the human EPOR gene is at 19p13 near the human LDLR locus.",

author = "M. Budarf and K. Huebner and B. Emanuel and Croce, {C. M.} and Copeland, {N. G.} and Jenkins, {N. A.} and D'Andrea, {A. D.}",

note = "Funding Information: We thank D. A. Swing, D. J. Gilbert, B. Cho, and M. Adams for excellent technical assistance. This research was supported, in part, by the National Cancer Institute, DHHS, under Contract NOl-CO-74101 with ABL and by Grants GM 32592, CA 39926, CA 39860, and KllHL02132-01 from the National Institutes of Health.",

year = "1990",

month = nov,

doi = "10.1016/0888-7543(90)90047-X",

language = "English (US)",

volume = "8",

pages = "575--578",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press",

number = "3",

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TY - JOUR

T1 - Assignment of the erythropoietin receptor (EPOR) gene to mouse chromosome 9 and human chromosome 19

AU - Budarf, M.

AU - Huebner, K.

AU - Emanuel, B.

AU - Croce, C. M.

AU - Copeland, N. G.

AU - Jenkins, N. A.

AU - D'Andrea, A. D.

N1 - Funding Information: We thank D. A. Swing, D. J. Gilbert, B. Cho, and M. Adams for excellent technical assistance. This research was supported, in part, by the National Cancer Institute, DHHS, under Contract NOl-CO-74101 with ABL and by Grants GM 32592, CA 39926, CA 39860, and KllHL02132-01 from the National Institutes of Health.

PY - 1990/11

Y1 - 1990/11

N2 - Erythropoietin (EPO), the primary regulator of mammalian erythropoiesis, binds and activates a specific receptor on erythroid progenitors. The human and mouse cDNAs for this receptor (EPOR) have recently been isolated. These cDNAs were used to establish the genomic location of the EPOR gene. By somatic cell hybrid analysis, the locus for the EPOR maps to human chromosome (Chr) 19pter-q12. By interspecific backcross mapping the locus is tightly linked to the murine Ldlr locus near the centromere of mouse Chr 9. This region of mouse Chr 9 is homologous to a region of human Chr 19p13 carrying the human LDLR and MEL loci, strongly suggesting that the human EPOR gene is at 19p13 near the human LDLR locus.

AB - Erythropoietin (EPO), the primary regulator of mammalian erythropoiesis, binds and activates a specific receptor on erythroid progenitors. The human and mouse cDNAs for this receptor (EPOR) have recently been isolated. These cDNAs were used to establish the genomic location of the EPOR gene. By somatic cell hybrid analysis, the locus for the EPOR maps to human chromosome (Chr) 19pter-q12. By interspecific backcross mapping the locus is tightly linked to the murine Ldlr locus near the centromere of mouse Chr 9. This region of mouse Chr 9 is homologous to a region of human Chr 19p13 carrying the human LDLR and MEL loci, strongly suggesting that the human EPOR gene is at 19p13 near the human LDLR locus.

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JO - Genomics

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Assignment of the erythropoietin receptor (EPOR) gene to mouse chromosome 9 and human chromosome 19

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