Assignment of a novel protein tyrosine phosphatase gene (Hcph) to mouse chromosome 6

Taolin Yi; Debra J. Gilbert; Nancy A. Jenkins; Neal G. Copeland; James N. Ihle

doi:10.1016/S0888-7543(05)80189-2

Assignment of a novel protein tyrosine phosphatase gene (Hcph) to mouse chromosome 6

Taolin Yi, Debra J. Gilbert, Nancy A. Jenkins, Neal G. Copeland, James N. Ihle

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Hematopoietic cell phosphatase (Hcph) was identified by amplification of conserved protein tyrosine phosphatase sequences from a myeloid cell line and is predominantly expressed in hematopoietic cells. Hcph is unique in containing two, tandemly repeated, src-homology 2 domains in the amino terminal region of the phosphatase. Using a genomic probe in interspecific backcross analysis, the murine Hcph gene maps to mouse Chromosome 6 and is tightly linked to the Tnfr-2 and Ly-4 genes.

Original language	English (US)
Pages (from-to)	793-795
Number of pages	3
Journal	Genomics
Volume	14
Issue number	3
DOIs	https://doi.org/10.1016/S0888-7543(05)80189-2
State	Published - Nov 1992

ASJC Scopus subject areas

Genetics

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10.1016/S0888-7543(05)80189-2

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@article{50ae10c28c4b48038a88c9d39dd24e87,

title = "Assignment of a novel protein tyrosine phosphatase gene (Hcph) to mouse chromosome 6",

abstract = "Hematopoietic cell phosphatase (Hcph) was identified by amplification of conserved protein tyrosine phosphatase sequences from a myeloid cell line and is predominantly expressed in hematopoietic cells. Hcph is unique in containing two, tandemly repeated, src-homology 2 domains in the amino terminal region of the phosphatase. Using a genomic probe in interspecific backcross analysis, the murine Hcph gene maps to mouse Chromosome 6 and is tightly linked to the Tnfr-2 and Ly-4 genes.",

author = "Taolin Yi and Gilbert, \{Debra J.\} and Jenkins, \{Nancy A.\} and Copeland, \{Neal G.\} and Ihle, \{James N.\}",

note = "Funding Information: This work was supported by the National Cancer Institute Cancer Center Support (CORE) Grant P30 CA21765, by Grant RO1 DK42932 from the National Institute of Diabetes and Digestive and Kidney Diseases, and by the American Lebanese Syrian Associated Charities (ALSAC). The research was also supported by the National Cancer Institute, DHHS, under contract NO1-CO-74101 with Advanced BioScience Laboratories, Inc. We thank Brian Cho and D. A. Swing for excellent technical assistance. J. N. Ihle holds an adjunct appointment in the Department of Biochemistry, University of Tennessee, Memphis, TN 38163. T. Yi is a Journey Fellow of St. Jude Children's Research Hospital.",

year = "1992",

month = nov,

doi = "10.1016/S0888-7543(05)80189-2",

language = "English (US)",

volume = "14",

pages = "793--795",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press",

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T1 - Assignment of a novel protein tyrosine phosphatase gene (Hcph) to mouse chromosome 6

AU - Yi, Taolin

AU - Gilbert, Debra J.

AU - Jenkins, Nancy A.

AU - Copeland, Neal G.

AU - Ihle, James N.

N1 - Funding Information: This work was supported by the National Cancer Institute Cancer Center Support (CORE) Grant P30 CA21765, by Grant RO1 DK42932 from the National Institute of Diabetes and Digestive and Kidney Diseases, and by the American Lebanese Syrian Associated Charities (ALSAC). The research was also supported by the National Cancer Institute, DHHS, under contract NO1-CO-74101 with Advanced BioScience Laboratories, Inc. We thank Brian Cho and D. A. Swing for excellent technical assistance. J. N. Ihle holds an adjunct appointment in the Department of Biochemistry, University of Tennessee, Memphis, TN 38163. T. Yi is a Journey Fellow of St. Jude Children's Research Hospital.

PY - 1992/11

Y1 - 1992/11

N2 - Hematopoietic cell phosphatase (Hcph) was identified by amplification of conserved protein tyrosine phosphatase sequences from a myeloid cell line and is predominantly expressed in hematopoietic cells. Hcph is unique in containing two, tandemly repeated, src-homology 2 domains in the amino terminal region of the phosphatase. Using a genomic probe in interspecific backcross analysis, the murine Hcph gene maps to mouse Chromosome 6 and is tightly linked to the Tnfr-2 and Ly-4 genes.

AB - Hematopoietic cell phosphatase (Hcph) was identified by amplification of conserved protein tyrosine phosphatase sequences from a myeloid cell line and is predominantly expressed in hematopoietic cells. Hcph is unique in containing two, tandemly repeated, src-homology 2 domains in the amino terminal region of the phosphatase. Using a genomic probe in interspecific backcross analysis, the murine Hcph gene maps to mouse Chromosome 6 and is tightly linked to the Tnfr-2 and Ly-4 genes.

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U2 - 10.1016/S0888-7543(05)80189-2

DO - 10.1016/S0888-7543(05)80189-2

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AN - SCOPUS:0026498611

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JO - Genomics

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ER -

Assignment of a novel protein tyrosine phosphatase gene (Hcph) to mouse chromosome 6

Abstract

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