Assessment of the Biological Effects of a Multifunctional Nano-Drug-Carrier and Its Encapsulated Drugs

Yipeng Song, Ruifang Zhao, Yili Hu, Fuhua Hao, Ning Li, Guangjun Nie, Huiru Tang, Yulan Wang

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Polymer-nanoparticle-encapsulated doxorubicin (DOX) and paclitaxel (TAX) have the potential for novel therapeutic use against cancer in the clinic. However, the systemic biological effect of the nanoparticle material, namely, methoxypoly(ethylene glycol)-poly(lactide-co-glycolide) (mPEG-PLGA), and its encapsulated drugs have not been fully studied. We have applied NMR-based metabonomics methodology to characterize and analyze the systemic metabolic changes in mice after being exposed to mPEG-PLGA, mPEG-PLGA-encapsulated DOX and TAX (NP-D/T), and their free forms. The study revealed that mPEG-PLGA exposure only induces temporary and slight metabolic alternations and that there are detoxification effects of nanoparticle packed with D/T drugs on the heart when comparing with free-form D/T drugs. Both NP-D/T and their free forms induce a shift in energy metabolism, stimulate antioxidation pathways, and disturb the gut microbial activity of the host. However, mPEG-PLGA packaging can relieve the energy metabolism inhibition and decrease the activation of antioxidation pathways caused by D/T exposure. These findings provide a holistic insight into the biological effect of polymer nanoparticle and nanoparticle-encapsulated drugs. This study also furthers our understanding of the molecular mechanisms involved in the amelioration effects of mPEG-PLGA packaging on the toxicity of the incorporated drugs.

Original languageEnglish (US)
Pages (from-to)5193-5201
Number of pages9
JournalJournal of Proteome Research
Volume14
Issue number12
DOIs
StatePublished - Dec 4 2015

Keywords

  • metabonomics
  • nanosafety
  • nanotoxicity
  • nuclear magnetic resonance (NMR)
  • polymer nanoparticles

ASJC Scopus subject areas

  • Biochemistry
  • Chemistry(all)

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