Assessment of Left Ventricular Relaxation by Untwisting Rate Based on Different Algorithms

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9 Scopus citations


Background: This study was performed in both animals and human subjects to test whether different approaches to calculate untwisting rate may lead to different results in the assessment of left ventricular (LV) relaxation. Methods: In animal experiments, congestive heart failure was successfully induced in 8 adult dogs. Transthoracic echocardiography was performed with simultaneous LV pressure recording at baseline and the stage of heart failure. In the clinical study, 72 patients undergoing right-sided heart catheterization were studied by transthoracic echocardiography. LV twist was calculated as the difference between apical and basal rotations measured using two-dimensional speckle tracking. Untwisting rate was calculated using 3 different algorithms as the peak negative time derivative of twist (URmax) during early diastole, the slope of the linear regression of untwisting over time (URslope), or the average untwisting over the isovolumic relaxation period (URmean). Results: URmax significantly correlated with tau and -dP/dt in dogs (r = -0.81 and 0.77, respectively, both P < .001) and was reduced at the stage of heart failure (P < .01). In 55 patients (76%) with adequate image quality, only URmax among untwisting rates calculated by 3 different algorithms was significantly related to tau (r = -0.51, P < .001). URmax was significantly lower in patients with tau ≥ 48 ms than in patients with tau < 48 ms (P = .004), most of whom had a depressed LV ejection fraction. Conclusion: URmax best reflects LV relaxation in comparison with the 2 other algorithms.

Original languageEnglish (US)
Pages (from-to)1040-1046
Number of pages7
JournalJournal of the American Society of Echocardiography
Issue number9
StatePublished - Sep 2009


  • Echocardiography
  • Two-dimensional speckle tracking
  • Untwisting rate

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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