Assessment of a superparamagnetic iron oxide (ami‐25) as a brain contrast agent

Thomas A. Kent, Michael J. Quast, Barry J. Kaplan, Robert S. Lifsey, Howard M. Eisenberg

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


We have applied a superparamagnetic iron oxide formulation (AMI‐25, Advanced Magnetics, Inc., Cambridge, MA) to image the cerebral vasculature. Contrast‐enhanced images of normal anesthetized rats demonstrated excellent gray/white matter differentiation, consistent with known differences in blood perfusion, and cerebrospinal fluid spaces were clearly seen. Alterations in normal perfusion patterns due to barbiturate anesthesia and ischemia were clearly visible. We propose the use of this agent as an adjunct to MRI for the imaging of conditions with perfusion abnormalities. © 1990 Academic Press, Inc.

Original languageEnglish (US)
Pages (from-to)434-443
Number of pages10
JournalMagnetic Resonance in Medicine
Issue number3
StatePublished - Mar 1990

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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