TY - JOUR
T1 - Assessment of a superparamagnetic iron oxide (ami‐25) as a brain contrast agent
AU - Kent, Thomas A.
AU - Quast, Michael J.
AU - Kaplan, Barry J.
AU - Lifsey, Robert S.
AU - Eisenberg, Howard M.
PY - 1990/1/1
Y1 - 1990/1/1
N2 - We have applied a superparamagnetic iron oxide formulation (AMI‐25, Advanced Magnetics, Inc., Cambridge, MA) to image the cerebral vasculature. Contrast‐enhanced images of normal anesthetized rats demonstrated excellent gray/white matter differentiation, consistent with known differences in blood perfusion, and cerebrospinal fluid spaces were clearly seen. Alterations in normal perfusion patterns due to barbiturate anesthesia and ischemia were clearly visible. We propose the use of this agent as an adjunct to MRI for the imaging of conditions with perfusion abnormalities. © 1990 Academic Press, Inc.
AB - We have applied a superparamagnetic iron oxide formulation (AMI‐25, Advanced Magnetics, Inc., Cambridge, MA) to image the cerebral vasculature. Contrast‐enhanced images of normal anesthetized rats demonstrated excellent gray/white matter differentiation, consistent with known differences in blood perfusion, and cerebrospinal fluid spaces were clearly seen. Alterations in normal perfusion patterns due to barbiturate anesthesia and ischemia were clearly visible. We propose the use of this agent as an adjunct to MRI for the imaging of conditions with perfusion abnormalities. © 1990 Academic Press, Inc.
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U2 - 10.1002/mrm.1910130310
DO - 10.1002/mrm.1910130310
M3 - Article
C2 - 2325543
AN - SCOPUS:0025392476
VL - 13
SP - 434
EP - 443
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
SN - 0740-3194
IS - 3
ER -