Assessing therapeutic efficacy in real-time by hyperpolarized magnetic resonance metabolic imaging

Prasanta Dutta, Travis C. Salzillo, Shivanand Pudakalakatti, Seth T. Gammon, Benny A. Kaipparettu, Florencia McAllister, Shawn Wagner, Daniel E. Frigo, Christopher J. Logothetis, Niki M. Zacharias, Pratip K. Bhattacharya

Research output: Contribution to journalArticlepeer-review

Abstract

Abstract: Precisely measuring tumor-associated alterations in metabolism clinically will enable the efficient assessment of therapeutic responses. Advances in imaging technologies can exploit the differences in cancer-associated cell metabolism as compared to normal tissue metabolism, linking changes in target metabolism to therapeutic efficacy. Metabolic imaging by Positron Emission Tomography (PET) employing 2-fluoro-deoxy-glucose ([18F]FDG) has been used as a routine diagnostic tool in the clinic. Recently developed hyperpolarized Magnetic Resonance (HP-MR), which radically increases the sensitivity of conventional MRI, has created a renewed interest in functional and metabolic imaging. The successful translation of this technique to the clinic was achieved recently with measurements of 13C-pyruvate metabolism. Here, we review the potential clinical roles for metabolic imaging with hyperpolarized MRI as applied in assessing therapeutic intervention in different cancer systems.

Original languageEnglish (US)
Article number340
JournalCells
Volume8
Issue number4
DOIs
StatePublished - Apr 2019

Keywords

  • Cancer metabolism
  • Hyperpolarization
  • Metabolic imaging
  • MRI
  • Therapy monitoring

ASJC Scopus subject areas

  • Medicine(all)

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