TY - JOUR
T1 - Assessing therapeutic efficacy in real-time by hyperpolarized magnetic resonance metabolic imaging
AU - Dutta, Prasanta
AU - Salzillo, Travis C.
AU - Pudakalakatti, Shivanand
AU - Gammon, Seth T.
AU - Kaipparettu, Benny A.
AU - McAllister, Florencia
AU - Wagner, Shawn
AU - Frigo, Daniel E.
AU - Logothetis, Christopher J.
AU - Zacharias, Niki M.
AU - Bhattacharya, Pratip K.
N1 - Publisher Copyright:
© 2019, MDPI AG. All rights reserved.
PY - 2019/4
Y1 - 2019/4
N2 - Abstract: Precisely measuring tumor-associated alterations in metabolism clinically will enable the efficient assessment of therapeutic responses. Advances in imaging technologies can exploit the differences in cancer-associated cell metabolism as compared to normal tissue metabolism, linking changes in target metabolism to therapeutic efficacy. Metabolic imaging by Positron Emission Tomography (PET) employing 2-fluoro-deoxy-glucose ([18F]FDG) has been used as a routine diagnostic tool in the clinic. Recently developed hyperpolarized Magnetic Resonance (HP-MR), which radically increases the sensitivity of conventional MRI, has created a renewed interest in functional and metabolic imaging. The successful translation of this technique to the clinic was achieved recently with measurements of 13C-pyruvate metabolism. Here, we review the potential clinical roles for metabolic imaging with hyperpolarized MRI as applied in assessing therapeutic intervention in different cancer systems.
AB - Abstract: Precisely measuring tumor-associated alterations in metabolism clinically will enable the efficient assessment of therapeutic responses. Advances in imaging technologies can exploit the differences in cancer-associated cell metabolism as compared to normal tissue metabolism, linking changes in target metabolism to therapeutic efficacy. Metabolic imaging by Positron Emission Tomography (PET) employing 2-fluoro-deoxy-glucose ([18F]FDG) has been used as a routine diagnostic tool in the clinic. Recently developed hyperpolarized Magnetic Resonance (HP-MR), which radically increases the sensitivity of conventional MRI, has created a renewed interest in functional and metabolic imaging. The successful translation of this technique to the clinic was achieved recently with measurements of 13C-pyruvate metabolism. Here, we review the potential clinical roles for metabolic imaging with hyperpolarized MRI as applied in assessing therapeutic intervention in different cancer systems.
KW - Cancer metabolism
KW - Hyperpolarization
KW - MRI
KW - Metabolic imaging
KW - Therapy monitoring
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U2 - 10.3390/cells8040340
DO - 10.3390/cells8040340
M3 - Article
AN - SCOPUS:85067064142
VL - 8
JO - Cells
JF - Cells
SN - 2073-4409
IS - 4
M1 - 340
ER -