Assessing therapeutic efficacy in real-time by hyperpolarized magnetic resonance metabolic imaging

Prasanta Dutta; Travis C. Salzillo; Shivanand Pudakalakatti; Seth T. Gammon; Benny A. Kaipparettu; Florencia McAllister; Shawn Wagner; Daniel E. Frigo; Christopher J. Logothetis; Niki M. Zacharias; Pratip K. Bhattacharya

doi:10.3390/cells8040340

Assessing therapeutic efficacy in real-time by hyperpolarized magnetic resonance metabolic imaging

Prasanta Dutta, Travis C. Salzillo, Shivanand Pudakalakatti, Seth T. Gammon, Benny A. Kaipparettu, Florencia McAllister, Shawn Wagner, Daniel E. Frigo, Christopher J. Logothetis, Niki M. Zacharias, Pratip K. Bhattacharya

Research output: Contribution to journal › Article › peer-review

Abstract

Abstract: Precisely measuring tumor-associated alterations in metabolism clinically will enable the efficient assessment of therapeutic responses. Advances in imaging technologies can exploit the differences in cancer-associated cell metabolism as compared to normal tissue metabolism, linking changes in target metabolism to therapeutic efficacy. Metabolic imaging by Positron Emission Tomography (PET) employing 2-fluoro-deoxy-glucose ([18F]FDG) has been used as a routine diagnostic tool in the clinic. Recently developed hyperpolarized Magnetic Resonance (HP-MR), which radically increases the sensitivity of conventional MRI, has created a renewed interest in functional and metabolic imaging. The successful translation of this technique to the clinic was achieved recently with measurements of 13C-pyruvate metabolism. Here, we review the potential clinical roles for metabolic imaging with hyperpolarized MRI as applied in assessing therapeutic intervention in different cancer systems.

Original language	English (US)
Article number	340
Journal	Cells
Volume	8
Issue number	4
DOIs	https://doi.org/10.3390/cells8040340
State	Published - Apr 2019

Keywords

Cancer metabolism
Hyperpolarization
Metabolic imaging
MRI
Therapy monitoring

ASJC Scopus subject areas

Medicine(all)

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10.3390/cells8040340

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Assessing therapeutic efficacy in real-time by hyperpolarized magnetic resonance metabolic imaging. / Dutta, Prasanta; Salzillo, Travis C.; Pudakalakatti, Shivanand; Gammon, Seth T.; Kaipparettu, Benny A.; McAllister, Florencia; Wagner, Shawn; Frigo, Daniel E.; Logothetis, Christopher J.; Zacharias, Niki M.; Bhattacharya, Pratip K.

In: Cells, Vol. 8, No. 4, 340, 04.2019.

Research output: Contribution to journal › Article › peer-review

Dutta, Prasanta ; Salzillo, Travis C. ; Pudakalakatti, Shivanand ; Gammon, Seth T. ; Kaipparettu, Benny A. ; McAllister, Florencia ; Wagner, Shawn ; Frigo, Daniel E. ; Logothetis, Christopher J. ; Zacharias, Niki M. ; Bhattacharya, Pratip K. / Assessing therapeutic efficacy in real-time by hyperpolarized magnetic resonance metabolic imaging. In: Cells. 2019 ; Vol. 8, No. 4.

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abstract = "Abstract: Precisely measuring tumor-associated alterations in metabolism clinically will enable the efficient assessment of therapeutic responses. Advances in imaging technologies can exploit the differences in cancer-associated cell metabolism as compared to normal tissue metabolism, linking changes in target metabolism to therapeutic efficacy. Metabolic imaging by Positron Emission Tomography (PET) employing 2-fluoro-deoxy-glucose ([18F]FDG) has been used as a routine diagnostic tool in the clinic. Recently developed hyperpolarized Magnetic Resonance (HP-MR), which radically increases the sensitivity of conventional MRI, has created a renewed interest in functional and metabolic imaging. The successful translation of this technique to the clinic was achieved recently with measurements of 13C-pyruvate metabolism. Here, we review the potential clinical roles for metabolic imaging with hyperpolarized MRI as applied in assessing therapeutic intervention in different cancer systems.",

keywords = "Cancer metabolism, Hyperpolarization, Metabolic imaging, MRI, Therapy monitoring",

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AU - Gammon, Seth T.

AU - Kaipparettu, Benny A.

AU - McAllister, Florencia

AU - Wagner, Shawn

AU - Frigo, Daniel E.

AU - Logothetis, Christopher J.

AU - Zacharias, Niki M.

AU - Bhattacharya, Pratip K.

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N2 - Abstract: Precisely measuring tumor-associated alterations in metabolism clinically will enable the efficient assessment of therapeutic responses. Advances in imaging technologies can exploit the differences in cancer-associated cell metabolism as compared to normal tissue metabolism, linking changes in target metabolism to therapeutic efficacy. Metabolic imaging by Positron Emission Tomography (PET) employing 2-fluoro-deoxy-glucose ([18F]FDG) has been used as a routine diagnostic tool in the clinic. Recently developed hyperpolarized Magnetic Resonance (HP-MR), which radically increases the sensitivity of conventional MRI, has created a renewed interest in functional and metabolic imaging. The successful translation of this technique to the clinic was achieved recently with measurements of 13C-pyruvate metabolism. Here, we review the potential clinical roles for metabolic imaging with hyperpolarized MRI as applied in assessing therapeutic intervention in different cancer systems.

AB - Abstract: Precisely measuring tumor-associated alterations in metabolism clinically will enable the efficient assessment of therapeutic responses. Advances in imaging technologies can exploit the differences in cancer-associated cell metabolism as compared to normal tissue metabolism, linking changes in target metabolism to therapeutic efficacy. Metabolic imaging by Positron Emission Tomography (PET) employing 2-fluoro-deoxy-glucose ([18F]FDG) has been used as a routine diagnostic tool in the clinic. Recently developed hyperpolarized Magnetic Resonance (HP-MR), which radically increases the sensitivity of conventional MRI, has created a renewed interest in functional and metabolic imaging. The successful translation of this technique to the clinic was achieved recently with measurements of 13C-pyruvate metabolism. Here, we review the potential clinical roles for metabolic imaging with hyperpolarized MRI as applied in assessing therapeutic intervention in different cancer systems.

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KW - Hyperpolarization

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Assessing therapeutic efficacy in real-time by hyperpolarized magnetic resonance metabolic imaging

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