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Assessing the changes in the biomechanical properties of the crystalline lens induced by cold cataract with air-pulse OCE

C. Wu, M. Singh, C. H. Liu, Z. Han, J. Li, R. Raghunathan, K. V. Larin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A cataract is the increase in opacity of the crystalline lens that can pathologically degrade visual acuity. In this study, we utilized a phase-sensitive optical coherence elastography (OCE) system to study the effects of a cold cataract on the biomechanical properties of the porcine crystalline lens in vitro. The cold cataract was induced by placing the whole lens in a low temperature environment until the lens was obviously clouded. Air-pulse OCE measurements were conducted on 6 lenses before and after cold cataract induction. A low amplitude displacement (≤ 10 μm) was induced by a focused air-pulse and the temporal deformation profiles from the surface and within the lenses were analyzed. The results demonstrated that the stiffness of the porcine lens increased after induction of the cold cataract, and it demonstrated the feasibility of OCE to assess the biomechanical changes in the lens due to cataract.

Original languageEnglish (US)
Title of host publicationNew Operational Technologies, NEWOT 2015
Subtitle of host publicationProceedings of the 5th International Scientific Conference "New Operational Technologies"
EditorsYury V. Kistenev, Yurii P. Sharkeev, Mikhail A. Sadovoy, Sergei N. Orlov
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735413351
DOIs
StatePublished - Nov 17 2015
Event5th International Scientific Conference on New Operational Technologies, NEWOT 2015 - Tomsk, Russian Federation
Duration: Sep 29 2015Sep 30 2015

Publication series

NameAIP Conference Proceedings
Volume1688
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference5th International Scientific Conference on New Operational Technologies, NEWOT 2015
Country/TerritoryRussian Federation
CityTomsk
Period9/29/159/30/15

ASJC Scopus subject areas

  • General Physics and Astronomy

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