Assessing Regurgitation Severity, Adverse Remodeling, and Fibrosis with CMR in Aortic Regurgitation

Mujtaba Saeed; Akila Bersali; Amr Darwish; Fatima Qamar; Dimitrios Maragiannis; Kinan Carlos El-Tallawi; Maan Malahfji; Dipan J. Shah

doi:10.1007/s11886-024-02044-3

Assessing Regurgitation Severity, Adverse Remodeling, and Fibrosis with CMR in Aortic Regurgitation

Mujtaba Saeed, Akila Bersali, Amr Darwish, Fatima Qamar, Dimitrios Maragiannis, Kinan Carlos El-Tallawi, Maan Malahfji, Dipan J. Shah

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

PURPOSE OF REVIEW: Cardiac magnetic resonance (CMR) is emerging as a valuable imaging modality for the assessment of aortic regurgitation (AR). In this review, we discuss the assessment of AR severity, left ventricular (LV) remodeling, and tissue characterization by CMR while highlighting the latest studies and addressing future research needs.

RECENT FINDINGS: Recent studies have further established CMR-based thresholds of AR severity and LV remodeling that are associated with adverse clinical outcomes, and lower than current guideline criteria. In addition, tissue profiling with late gadolinium enhancement (LGE) and extracellular volume (ECV) quantification can reliably assess adverse myocardial tissue remodeling which is also associated with adverse outcomes. The strengths and reproducibility of CMR in evaluating ventricular volumes, tissue characteristics, and regurgitation severity position it as an excellent modality in evaluating and following AR patients. Advanced CMR techniques for the detection of tissue remodeling have shown significant potential and merit further investigation.

Original language	English (US)
Pages (from-to)	413-421
Number of pages	9
Journal	Current Cardiology Reports
Volume	26
Issue number	5
DOIs	https://doi.org/10.1007/s11886-024-02044-3
State	Published - May 2024

Keywords

Aortic regurgitation
Cardiac magnetic resonance
Myocardial fibrosis
Myocardial remodeling
Phase-contrast imaging
Severity of Illness Index
Reproducibility of Results
Humans
Magnetic Resonance Imaging/methods
Magnetic Resonance Imaging, Cine/methods
Ventricular Remodeling
Contrast Media
Fibrosis/diagnostic imaging
Aortic Valve Insufficiency/diagnostic imaging

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1007/s11886-024-02044-3

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title = "Assessing Regurgitation Severity, Adverse Remodeling, and Fibrosis with CMR in Aortic Regurgitation",

abstract = "PURPOSE OF REVIEW: Cardiac magnetic resonance (CMR) is emerging as a valuable imaging modality for the assessment of aortic regurgitation (AR). In this review, we discuss the assessment of AR severity, left ventricular (LV) remodeling, and tissue characterization by CMR while highlighting the latest studies and addressing future research needs.RECENT FINDINGS: Recent studies have further established CMR-based thresholds of AR severity and LV remodeling that are associated with adverse clinical outcomes, and lower than current guideline criteria. In addition, tissue profiling with late gadolinium enhancement (LGE) and extracellular volume (ECV) quantification can reliably assess adverse myocardial tissue remodeling which is also associated with adverse outcomes. The strengths and reproducibility of CMR in evaluating ventricular volumes, tissue characteristics, and regurgitation severity position it as an excellent modality in evaluating and following AR patients. Advanced CMR techniques for the detection of tissue remodeling have shown significant potential and merit further investigation.",

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AU - Qamar, Fatima

AU - Maragiannis, Dimitrios

AU - El-Tallawi, Kinan Carlos

AU - Malahfji, Maan

AU - Shah, Dipan J.

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AB - PURPOSE OF REVIEW: Cardiac magnetic resonance (CMR) is emerging as a valuable imaging modality for the assessment of aortic regurgitation (AR). In this review, we discuss the assessment of AR severity, left ventricular (LV) remodeling, and tissue characterization by CMR while highlighting the latest studies and addressing future research needs.RECENT FINDINGS: Recent studies have further established CMR-based thresholds of AR severity and LV remodeling that are associated with adverse clinical outcomes, and lower than current guideline criteria. In addition, tissue profiling with late gadolinium enhancement (LGE) and extracellular volume (ECV) quantification can reliably assess adverse myocardial tissue remodeling which is also associated with adverse outcomes. The strengths and reproducibility of CMR in evaluating ventricular volumes, tissue characteristics, and regurgitation severity position it as an excellent modality in evaluating and following AR patients. Advanced CMR techniques for the detection of tissue remodeling have shown significant potential and merit further investigation.

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KW - Contrast Media

KW - Fibrosis/diagnostic imaging

KW - Aortic Valve Insufficiency/diagnostic imaging

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Assessing Regurgitation Severity, Adverse Remodeling, and Fibrosis with CMR in Aortic Regurgitation

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