TY - JOUR
T1 - Assessing Regurgitation Severity, Adverse Remodeling, and Fibrosis with CMR in Aortic Regurgitation
AU - Saeed, Mujtaba
AU - Bersali, Akila
AU - Darwish, Amr
AU - Qamar, Fatima
AU - Maragiannis, Dimitrios
AU - El-Tallawi, Kinan Carlos
AU - Malahfji, Maan
AU - Shah, Dipan J.
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
PY - 2024/5
Y1 - 2024/5
N2 - PURPOSE OF REVIEW: Cardiac magnetic resonance (CMR) is emerging as a valuable imaging modality for the assessment of aortic regurgitation (AR). In this review, we discuss the assessment of AR severity, left ventricular (LV) remodeling, and tissue characterization by CMR while highlighting the latest studies and addressing future research needs.RECENT FINDINGS: Recent studies have further established CMR-based thresholds of AR severity and LV remodeling that are associated with adverse clinical outcomes, and lower than current guideline criteria. In addition, tissue profiling with late gadolinium enhancement (LGE) and extracellular volume (ECV) quantification can reliably assess adverse myocardial tissue remodeling which is also associated with adverse outcomes. The strengths and reproducibility of CMR in evaluating ventricular volumes, tissue characteristics, and regurgitation severity position it as an excellent modality in evaluating and following AR patients. Advanced CMR techniques for the detection of tissue remodeling have shown significant potential and merit further investigation.
AB - PURPOSE OF REVIEW: Cardiac magnetic resonance (CMR) is emerging as a valuable imaging modality for the assessment of aortic regurgitation (AR). In this review, we discuss the assessment of AR severity, left ventricular (LV) remodeling, and tissue characterization by CMR while highlighting the latest studies and addressing future research needs.RECENT FINDINGS: Recent studies have further established CMR-based thresholds of AR severity and LV remodeling that are associated with adverse clinical outcomes, and lower than current guideline criteria. In addition, tissue profiling with late gadolinium enhancement (LGE) and extracellular volume (ECV) quantification can reliably assess adverse myocardial tissue remodeling which is also associated with adverse outcomes. The strengths and reproducibility of CMR in evaluating ventricular volumes, tissue characteristics, and regurgitation severity position it as an excellent modality in evaluating and following AR patients. Advanced CMR techniques for the detection of tissue remodeling have shown significant potential and merit further investigation.
KW - Aortic regurgitation
KW - Cardiac magnetic resonance
KW - Myocardial fibrosis
KW - Myocardial remodeling
KW - Phase-contrast imaging
KW - Severity of Illness Index
KW - Reproducibility of Results
KW - Humans
KW - Magnetic Resonance Imaging/methods
KW - Magnetic Resonance Imaging, Cine/methods
KW - Ventricular Remodeling
KW - Contrast Media
KW - Fibrosis/diagnostic imaging
KW - Aortic Valve Insufficiency/diagnostic imaging
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U2 - 10.1007/s11886-024-02044-3
DO - 10.1007/s11886-024-02044-3
M3 - Article
C2 - 38517604
AN - SCOPUS:85188448160
SN - 1523-3782
VL - 26
SP - 413
EP - 421
JO - Current Cardiology Reports
JF - Current Cardiology Reports
IS - 5
ER -