Assessing low levels of high-density lipoprotein cholesterol as a risk factor in coronary heart disease: A working group report and update

Antonio M. Gotto, Eliot A. Brinton

Research output: Contribution to journalReview article

190 Scopus citations

Abstract

Clinical data show that a 1% increase in serum concentrations of high-density lipoprotein cholesterol (HDL-C) can decrease cardiovascular risk by 2% to 3%. Therefore, mechanisms affecting the level and functionality of high-density lipoprotein (HDL) and its constituents are being investigated as targets for the rational development of drugs to prevent or treat cardiovascular disease. High-density lipoprotein-related research may also increase our understanding of the link between atherosclerosis and metabolic disorders. This report and update of the HDL Working Group discusses HDL metabolism and reverse cholesterol transport, impaired HDL as a marker and a cause of proatherogenic states, and experimental and current approaches to HDL-related therapy.

Original languageEnglish (US)
Pages (from-to)717-724
Number of pages8
JournalJournal of the American College of Cardiology
Volume43
Issue number5
DOIs
StatePublished - Mar 3 2004

Keywords

  • ABC-A1
  • Adenosine triphosphate binding cassette-A1
  • Apo
  • Apolipoprotein
  • CETP
  • CHD
  • Cholesteryl ester transfer protein
  • Coronary heart disease
  • FCR
  • Fractional catabolic rate
  • HDL-C
  • Hepatic lipase
  • High-density lipoprotein cholesterol
  • HL
  • LCAT

ASJC Scopus subject areas

  • Nursing(all)

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