TY - GEN
T1 - Assessing corneal viscoelasticity after crosslinking at different IOP by noncontact OCE and a modified Lamb wave model
AU - Han, Zhaolong
AU - Li, Jiasong
AU - Singh, Manmohan
AU - Wu, Chen
AU - Liu, Chih Hao
AU - Raghunathan, Raksha
AU - Aglyamov, Salavat R.
AU - Vantipalli, Srilatha
AU - Twa, Michael D.
AU - Larin, Kirill V.
N1 - Publisher Copyright:
© 2017 SPIE.
PY - 2017
Y1 - 2017
N2 - UV-A/riboflavin collagen cross-linking (UV-CXL) is a clinical treatment for keratoconus that stiffens mechanically degraded corneal tissue. On the other hand, the intraocular pressure (IOP) can also affect the measured cornea elasticity. However, the combined effects of CXL at different IOPs on the corneal biomechanical properties are not well understood. In this work, the feasibility of assessing the viscoelasticity of the porcine cornea before and after CXL at various IOPs was investigated by using a noncontact method of optical coherence elastography (OCE) and a modified Lamb wave model. The modified wave model was first verified by comparison with finite element modeling, and then utilized to quantify the viscoelasticity of porcine corneas in the whole eye-globe configuration before and after CXL treatment at various IOPs. The results show that the elasticity of the cornea increased after CXL and that corneal stiffness was linear as a function of IOP. At IOPs of 15, 20, 25, and 30 mmHg, the relative increase in Young's modulus after CXL was ∼109%, ∼86%, ∼64%, and ∼79%, respectively, while the shear viscosity decreased by ∼86%, ∼84%, ∼83%, and ∼81%. The modified Lamb wave model and OCE show promise for quantifying corneal viscoelasticity, which could provide a basis for customized CXL therapies and accurate disease detection.
AB - UV-A/riboflavin collagen cross-linking (UV-CXL) is a clinical treatment for keratoconus that stiffens mechanically degraded corneal tissue. On the other hand, the intraocular pressure (IOP) can also affect the measured cornea elasticity. However, the combined effects of CXL at different IOPs on the corneal biomechanical properties are not well understood. In this work, the feasibility of assessing the viscoelasticity of the porcine cornea before and after CXL at various IOPs was investigated by using a noncontact method of optical coherence elastography (OCE) and a modified Lamb wave model. The modified wave model was first verified by comparison with finite element modeling, and then utilized to quantify the viscoelasticity of porcine corneas in the whole eye-globe configuration before and after CXL treatment at various IOPs. The results show that the elasticity of the cornea increased after CXL and that corneal stiffness was linear as a function of IOP. At IOPs of 15, 20, 25, and 30 mmHg, the relative increase in Young's modulus after CXL was ∼109%, ∼86%, ∼64%, and ∼79%, respectively, while the shear viscosity decreased by ∼86%, ∼84%, ∼83%, and ∼81%. The modified Lamb wave model and OCE show promise for quantifying corneal viscoelasticity, which could provide a basis for customized CXL therapies and accurate disease detection.
KW - Cornea
KW - Crosslinking
KW - Intraocular pressure
KW - Optical coherence elastography
KW - Rayleigh-Lamb wave
KW - Shear viscosity
KW - Young's modulus
UR - https://www.scopus.com/pages/publications/85018887754
UR - https://www.scopus.com/inward/citedby.url?scp=85018887754&partnerID=8YFLogxK
U2 - 10.1117/12.2251784
DO - 10.1117/12.2251784
M3 - Conference contribution
AN - SCOPUS:85018887754
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Opthalmic Technologies XXVII
A2 - Soderberg, Per G.
A2 - Ho, Arthur
A2 - Manns, Fabrice
PB - SPIE
T2 - 27th Conference on Ophthalmic Technologies
Y2 - 28 January 2017 through 29 January 2017
ER -