Aspirin Inhibits Colon Cancer Cell and Tumor Growth and Downregulates Specificity Protein (Sp) Transcription Factors

Agriculture & Biology

• colorectal neoplasms 70%
• aspirin 69%
• neoplasm cells 52%
• cell growth 48%
• transcription factors 45%
• neoplasms 44%
• proteins 19%
• salicylates 18%
• apoptosis 8%
• mechanism of action 8%
• catenins 8%
• sodium salicylate 7%
• metabolites 6%
• caspases 6%
• zinc sulfate 6%
• cyclins 5%
• antineoplastic agents 5%
• RNA interference 4%
• animal models 4%
• cleavage (chemistry) 4%
• growth retardation 4%
• zinc 3%
• sodium 3%
• ions 3%
• genes 3%
• salts 3%
• metabolism 2%

Medicine & Life Sciences

• Sp Transcription Factors 100%
• Aspirin 53%
• Colonic Neoplasms 52%
• Down-Regulation 40%
• Growth 29%
• Neoplasms 18%
• Salicylates 18%
• Proteins 10%
• Nude Mice 9%
• Sodium Salicylate 7%
• Zinc Sulfate 6%
• Catenins 6%
• Apoptosis 5%
• Survivin 5%
• Cyclin D1 5%
• Caspases 4%
• RNA Interference 4%
• Antineoplastic Agents 4%
• Zinc 4%
• Heterografts 4%
• Salts 4%
• Vascular Endothelial Growth Factor A 4%
• Sodium 4%
• Ions 3%
• Serum 2%

Chemistry

• Salicylate 52%
• Protein 23%
• Cell Growth Inhibition 21%
• Metabolite 20%
• Sodium Salicylate 20%
• Zinc Sulfate 19%
• Acetylsalicylic Acid 18%
• Zinc Ion 15%
• Sodium Salt 14%
• Antineoplastic Agent 12%
• Pharmacological Metabolism 11%
• Cleavage 9%