Aspiration biopsy of osseous metastasis of retroperitoneal paraganglioma: Report of a case with cytologic features and differential diagnostic considerations

K. J. Absher, D. A. Witte, Luan Truong, I. Ramzy, Dina R. Mody, M. L. Ostrowski

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

BACKGROUND: Paragangliomas are uncommon tumors, only 10% of which are malignant, as evidenced by metastatic disease. It is rare for paraganglioma to present with symptomatic osseous metastases. CASE: A retroperitoneal paraganglioma presented in a 52-year-old man as painful metastases in the rib and vertebrae. Fine needle aspiration (FNA) of a lumbar vertebral lesion showed cells arranged singly and in loose clusters with fragile, vacuolated or finely granular cytoplasm, marked anisonucleosis and mitoses. Rare zellballen-type structures and intranuclear inclusions were present. Immunohistochemical studies of a subsequent FNA core biopsy of the retroperitoneal mass showed strong immunoreactivity with chromogranin and negative staining for keratin; that was helpful in differentiating this tumor from others in the differential diagnosis. CONCLUSION: The cytologic diagnosis of paraganglioma is difficult as these tumors exhibit a plethora of features that overlap those of many other neoplasms. The diagnosis can be confirmed with appropriate immunohistochemical studies of corresponding core biopsies.

Original languageEnglish (US)
Pages (from-to)249-253
Number of pages5
JournalActa Cytologica
Volume45
Issue number2
DOIs
StatePublished - Jan 1 2001

Keywords

  • Aspiration biopsy
  • Bone neoplasms
  • Metastasis
  • Paraganglioma
  • Retroperitoneal neoplasms

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology
  • Histology

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