TY - JOUR
T1 - Aryl hydrocarbon receptor (AhR) ligands as selective AhR modulators
T2 - Genomic studies
AU - Safe, Stephen
AU - Han, Huajun
AU - Goldsby, Jennifer
AU - Mohankumar, Kumaravel
AU - Chapkin, Robert S.
N1 - Funding Information:
We would like to thank Rachel C. Wright for generation of the gene expression heat maps. Funding was provided by Texas AgriLife Research , the Sid Kyle Chair Endowment, the Allen Endowed Chair in Nutrition & Chronic Disease Prevention, the Cancer Prevention Research Institute of Texas ( RP160589 ); and the National Institutes of Health ( R01-ES025713 , R01-CA202697 , R35-CA197707 ).
Publisher Copyright:
© 2018
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2018/10/1
Y1 - 2018/10/1
N2 - The aryl hydrocarbon receptor (AhR) binds structurally diverse ligands that vary from the environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to AhR-active pharmaceuticals and health-promoting phytochemicals. There are remarkable differences in the toxicity of TCDD and related halogenated aromatics (HAs) vs. health promoting AhR ligands, and genomic analysis shows that even among the toxic HAs, there are differences in their regulation of genes and pathways. Thus, like ligands for other receptors, AhR ligands are selective AhR modulators (SAhRMs) which exhibit variable tissue-, organ- and species-specific genomic and functional activities.
AB - The aryl hydrocarbon receptor (AhR) binds structurally diverse ligands that vary from the environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to AhR-active pharmaceuticals and health-promoting phytochemicals. There are remarkable differences in the toxicity of TCDD and related halogenated aromatics (HAs) vs. health promoting AhR ligands, and genomic analysis shows that even among the toxic HAs, there are differences in their regulation of genes and pathways. Thus, like ligands for other receptors, AhR ligands are selective AhR modulators (SAhRMs) which exhibit variable tissue-, organ- and species-specific genomic and functional activities.
KW - AhR
KW - Ligands
KW - Structure-activity genomic differences
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U2 - 10.1016/j.cotox.2018.11.005
DO - 10.1016/j.cotox.2018.11.005
M3 - Review article
AN - SCOPUS:85057847813
SN - 2468-2020
VL - 11-12
SP - 10
EP - 20
JO - Current Opinion in Toxicology
JF - Current Opinion in Toxicology
ER -