Aryl hydrocarbon receptor (AhR) ligands as selective AhR modulators: Genomic studies

Stephen Safe, Huajun Han, Jennifer Goldsby, Kumaravel Mohankumar, Robert S. Chapkin

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

The aryl hydrocarbon receptor (AhR) binds structurally diverse ligands that vary from the environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to AhR-active pharmaceuticals and health-promoting phytochemicals. There are remarkable differences in the toxicity of TCDD and related halogenated aromatics (HAs) vs. health promoting AhR ligands, and genomic analysis shows that even among the toxic HAs, there are differences in their regulation of genes and pathways. Thus, like ligands for other receptors, AhR ligands are selective AhR modulators (SAhRMs) which exhibit variable tissue-, organ- and species-specific genomic and functional activities.

Original languageEnglish (US)
Pages (from-to)10-20
Number of pages11
JournalCurrent Opinion in Toxicology
Volume11-12
DOIs
StatePublished - Oct 1 2018

Keywords

  • AhR
  • Ligands
  • Structure-activity genomic differences

ASJC Scopus subject areas

  • Toxicology

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