ARTreat project: Three-dimensional numerical simulation of plaque formation and development in the arteries

Nenad Filipovic; Mirko Rosic; Irena Tanaskovic; Zarko Milosevic; Dalibor Nikolic; Nebojsa Zdravkovic; Aleksandar Peulic; Milos R. Kojic; Dimitris I. Fotiadis; Oberdan Parodi

doi:10.1109/TITB.2011.2168418

ARTreat project: Three-dimensional numerical simulation of plaque formation and development in the arteries

Nenad Filipovic, Mirko Rosic, Irena Tanaskovic, Zarko Milosevic, Dalibor Nikolic, Nebojsa Zdravkovic, Aleksandar Peulic, Milos R. Kojic, Dimitris I. Fotiadis, Oberdan Parodi

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in arteries. It is characterized by dysfunction of endothelium and vasculitis, and accumulation of lipid, cholesterol, and cell elements inside blood vessel wall. In this study, a continuum-based approach for plaque formation and development in 3-D is presented. The blood flow is simulated by the 3-D Navier-Stokes equations, together with the continuity equation while low-density lipoprotein (LDL) transport in lumen of the vessel is coupled with Kedem-Katchalsky equations. The inflammatory process was solved using three additional reaction-diffusion partial differential equations. Transport of labeled LDL was fitted with our experiment on the rabbit animal model. Matching with histological data for LDL localization was achieved. Also, 3-D model of the straight artery with initial mild constriction of 30 plaque for formation and development is presented.

Original language	English (US)
Article number	6021373
Pages (from-to)	272-278
Number of pages	7
Journal	IEEE Transactions on Information Technology in Biomedicine
Volume	16
Issue number	2
DOIs	https://doi.org/10.1109/TITB.2011.2168418
State	Published - Mar 2012

Keywords

Atherosclerosis
low-density lipoprotein (LDL)
plaque
wall shear stress

ASJC Scopus subject areas

Electrical and Electronic Engineering
Biotechnology
Computer Science Applications
Medicine(all)

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10.1109/TITB.2011.2168418

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Filipovic, N., Rosic, M., Tanaskovic, I., Milosevic, Z., Nikolic, D., Zdravkovic, N., Peulic, A., Kojic, M. R., Fotiadis, D. I., & Parodi, O. (2012). ARTreat project: Three-dimensional numerical simulation of plaque formation and development in the arteries. IEEE Transactions on Information Technology in Biomedicine, 16(2), 272-278. Article 6021373. https://doi.org/10.1109/TITB.2011.2168418

Filipovic, N, Rosic, M, Tanaskovic, I, Milosevic, Z, Nikolic, D, Zdravkovic, N, Peulic, A, Kojic, MR, Fotiadis, DI & Parodi, O 2012, 'ARTreat project: Three-dimensional numerical simulation of plaque formation and development in the arteries', IEEE Transactions on Information Technology in Biomedicine, vol. 16, no. 2, 6021373, pp. 272-278. https://doi.org/10.1109/TITB.2011.2168418

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abstract = "Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in arteries. It is characterized by dysfunction of endothelium and vasculitis, and accumulation of lipid, cholesterol, and cell elements inside blood vessel wall. In this study, a continuum-based approach for plaque formation and development in 3-D is presented. The blood flow is simulated by the 3-D Navier-Stokes equations, together with the continuity equation while low-density lipoprotein (LDL) transport in lumen of the vessel is coupled with Kedem-Katchalsky equations. The inflammatory process was solved using three additional reaction-diffusion partial differential equations. Transport of labeled LDL was fitted with our experiment on the rabbit animal model. Matching with histological data for LDL localization was achieved. Also, 3-D model of the straight artery with initial mild constriction of 30 plaque for formation and development is presented.",

keywords = "Atherosclerosis, low-density lipoprotein (LDL), plaque, wall shear stress",

author = "Nenad Filipovic and Mirko Rosic and Irena Tanaskovic and Zarko Milosevic and Dalibor Nikolic and Nebojsa Zdravkovic and Aleksandar Peulic and Kojic, {Milos R.} and Fotiadis, {Dimitris I.} and Oberdan Parodi",

note = "Funding Information: Manuscript received April 15, 2011; revised July 26, 2011; accepted August 30, 2011. Date of publication September 19, 2011; date of current version March 7, 2012. This work was supported by the European Commission under Project ARTreat, ICT 224297 and the Serbian Ministry of Science under Project III-41007 and Project ON-174028.",

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doi = "10.1109/TITB.2011.2168418",

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AU - Rosic, Mirko

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AU - Nikolic, Dalibor

AU - Zdravkovic, Nebojsa

AU - Peulic, Aleksandar

AU - Kojic, Milos R.

AU - Fotiadis, Dimitris I.

AU - Parodi, Oberdan

N1 - Funding Information: Manuscript received April 15, 2011; revised July 26, 2011; accepted August 30, 2011. Date of publication September 19, 2011; date of current version March 7, 2012. This work was supported by the European Commission under Project ARTreat, ICT 224297 and the Serbian Ministry of Science under Project III-41007 and Project ON-174028.

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N2 - Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in arteries. It is characterized by dysfunction of endothelium and vasculitis, and accumulation of lipid, cholesterol, and cell elements inside blood vessel wall. In this study, a continuum-based approach for plaque formation and development in 3-D is presented. The blood flow is simulated by the 3-D Navier-Stokes equations, together with the continuity equation while low-density lipoprotein (LDL) transport in lumen of the vessel is coupled with Kedem-Katchalsky equations. The inflammatory process was solved using three additional reaction-diffusion partial differential equations. Transport of labeled LDL was fitted with our experiment on the rabbit animal model. Matching with histological data for LDL localization was achieved. Also, 3-D model of the straight artery with initial mild constriction of 30 plaque for formation and development is presented.

AB - Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in arteries. It is characterized by dysfunction of endothelium and vasculitis, and accumulation of lipid, cholesterol, and cell elements inside blood vessel wall. In this study, a continuum-based approach for plaque formation and development in 3-D is presented. The blood flow is simulated by the 3-D Navier-Stokes equations, together with the continuity equation while low-density lipoprotein (LDL) transport in lumen of the vessel is coupled with Kedem-Katchalsky equations. The inflammatory process was solved using three additional reaction-diffusion partial differential equations. Transport of labeled LDL was fitted with our experiment on the rabbit animal model. Matching with histological data for LDL localization was achieved. Also, 3-D model of the straight artery with initial mild constriction of 30 plaque for formation and development is presented.

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ARTreat project: Three-dimensional numerical simulation of plaque formation and development in the arteries

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