ARTreat project: Three-dimensional numerical simulation of plaque formation and development in the arteries

Nenad Filipovic, Mirko Rosic, Irena Tanaskovic, Zarko Milosevic, Dalibor Nikolic, Nebojsa Zdravkovic, Aleksandar Peulic, Milos R. Kojic, Dimitris I. Fotiadis, Oberdan Parodi

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in arteries. It is characterized by dysfunction of endothelium and vasculitis, and accumulation of lipid, cholesterol, and cell elements inside blood vessel wall. In this study, a continuum-based approach for plaque formation and development in 3-D is presented. The blood flow is simulated by the 3-D Navier-Stokes equations, together with the continuity equation while low-density lipoprotein (LDL) transport in lumen of the vessel is coupled with Kedem-Katchalsky equations. The inflammatory process was solved using three additional reaction-diffusion partial differential equations. Transport of labeled LDL was fitted with our experiment on the rabbit animal model. Matching with histological data for LDL localization was achieved. Also, 3-D model of the straight artery with initial mild constriction of 30 plaque for formation and development is presented.

Original languageEnglish (US)
Article number6021373
Pages (from-to)272-278
Number of pages7
JournalIEEE Transactions on Information Technology in Biomedicine
Volume16
Issue number2
DOIs
StatePublished - Mar 2012

Keywords

  • Atherosclerosis
  • low-density lipoprotein (LDL)
  • plaque
  • wall shear stress

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Biotechnology
  • Computer Science Applications
  • Medicine(all)

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