Arterial Wall Stiffness and Atherogenesis in Human Coronaries

Jacques Ohayon , Saami K. Yazdani, Mauro Malvè, Ahmed M. Gharib, Alberto Garcia, Gérard Finet, Roderic I. Pettigrew

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

The present study hypothesized that local wall-strain stiffening phenomena might, in addition to low endothelial shear stress (ESS) and cyclic stretch, be a complementary factor in plaque location in coronary bifurcations. Patients with minimal coronary disease, having undergone both computer tomography and magnetic resonance imaging examinations, were enrolled for the study. Both computational fluid dynamics and structural analysis were performed. The effects of cardiac motion and blood pressure on spatial luminal arterial wall stretch (LWstretch), and stiffness (LWstiff) distributions in the left main coronary bifurcations, were investigated. No correlations were found between LWStiff, LWStretch, and ESS at lesion sites. However, results indicated that 89% of lesions were located at sites of low ESS (i.e., ESS<1Pa) and, more interestingly, also in specific regions of high LWStiff (LWStiff>300kPa). These findings underline the importance of arterial wall stiffness in the development of atherosclerosis.

Original languageEnglish (US)
Title of host publicationBiomechanics of Living Organs
Subtitle of host publicationHyperelastic Constitutive Laws for Finite Element Modeling
PublisherElsevier
Pages193-213
Number of pages21
ISBN (Electronic)9780128040607
ISBN (Print)9780128040096
DOIs
StatePublished - Jan 1 2017

Keywords

  • Atherosclerosis
  • Biomechanics
  • Coronary disease
  • Endothelial shear stress
  • Finite element analysis
  • Fluid mechanics
  • Solid mechanics
  • Wall stiffness
  • Wall stress

ASJC Scopus subject areas

  • Medicine(all)

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