Aroclor 1254 as an antagonist of the teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin

J. M. Haake, S. Safe, K. Mayura, T. D. Phillips

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

Administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, 20 μg kg) to pregnant C57BL/6J mice (on day 10) resulted in 62% fetuses with cleft palate per litter without any observable maternal toxicity. In contrast, Aroclor 1254 administered at a dose of 750 μmol kg was not teratogenic. Cotreatment of the pregnant mice with both Aroclor 1254 (244 mg kg) and 2,3,7,8-TCDD (20 μg kg) resulted in an 8.2% incidence of cleft palate per litter. In contrast, Aroclor 1254 did not afford any protection from the teratogenicity of dexamethasone in C57BL/6J mice. Previous studies have shown that Aroclor 1254 can act as a partial antagonist of the microsomal enzyme induction and immunotoxic effects of 2,3,7,8-TCDD in C57BL/6J mice and this paper demonstrates that the commercial polychlorinated biphenyl mixture also antagonizes 2,3,7,8-TCDD-mediated teratogenicity in this strain of mice.

Original languageEnglish (US)
Pages (from-to)299-306
Number of pages8
JournalToxicology Letters
Volume38
Issue number3
DOIs
StatePublished - Oct 1987

Keywords

  • (Aroclor 1254
  • 2,3,7,8-TCDD
  • antagonism)

ASJC Scopus subject areas

  • Toxicology

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