Abstract
Background: Maximizing patient and allograft survival after liver transplant (LT) is important from both a patient care and organ utilization perspective. Although individual studies have addressed the effects of short-term post-LT complications on a limited scale, there has not been a systematic review of the literature formally assessing the potential effects of early complications on long-term outcomes. Objectives: To identify whether short-term complications after LT affect allograft and overall survival, to identify short-term complications of particular clinical interest and significance, and to provide recommendations to improve post-LT graft and patient survival. Data sources: Ovid MEDLINE, Embase, Scopus, Google Scholar, and Cochrane Central. Methods: A systematic review following PRISMA guidelines and recommendations using the GRADE approach derived from an international expert panel. Results: The literature review and analysis provided show that short-term complications have a large impact on allograft and patient survival after LT. The complications with the strongest effect on survival are acute kidney injury (AKI), biliary complications, and early allograft dysfunction (EAD). Conclusion: This panel recommends taking measures to reduce the risk and incidence of short-term complications post-LT. Clinicians should pay particular attention to preventing or ameliorating AKI, biliary complications, and EAD (Quality of evidence; Moderate | Grade of Recommendation; Strong).
Original language | English (US) |
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Article number | e14704 |
Pages (from-to) | e14704 |
Journal | Clinical Transplantation |
Volume | 36 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2022 |
Keywords
- allograft survival
- complications
- liver transplantation
- morbidity
- patient survival
- recipient survival
- short-term outcomes
- Humans
- Risk Factors
- Graft Survival
- Acute Kidney Injury/etiology
- Primary Graft Dysfunction/etiology
- Allografts
- Liver Transplantation/adverse effects
ASJC Scopus subject areas
- Transplantation