TY - JOUR
T1 - Applications of gene transfer in hematologic malignancy.
AU - Brenner, M. K.
N1 - Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 1998
Y1 - 1998
N2 - Although gene transfer was originally conceived as a means to replace or correct defective genes in patients with inherited disorders, the process has shown broad potential for intervention in hematologic malignancy and for study of hematopoietic stem cell biology. Gene transfer strategies now under investigation for these applications include 1) repair of one or more genetic defects associated with the malignant process, 2) delivery of a prodrug-metabolizing enzyme that causes tumor cells to become sensitive to the corresponding anticancer drug, 3) modification of immune responses to the cancer, and 4) introduction of drug resistance genes to increase the therapeutic index of cytotoxic agents. Finally, by marking normal or malignant cells with readily detectable genes, one can monitor the efficacy of therapy or study the dynamics of stem cell behavior in vivo. At present these applications are limited by the quality of vectors, but as transduction efficiencies and gene regulatory mechanisms improve, gene transfer can be expected to evolve into a major therapeutic modality in its own right.
AB - Although gene transfer was originally conceived as a means to replace or correct defective genes in patients with inherited disorders, the process has shown broad potential for intervention in hematologic malignancy and for study of hematopoietic stem cell biology. Gene transfer strategies now under investigation for these applications include 1) repair of one or more genetic defects associated with the malignant process, 2) delivery of a prodrug-metabolizing enzyme that causes tumor cells to become sensitive to the corresponding anticancer drug, 3) modification of immune responses to the cancer, and 4) introduction of drug resistance genes to increase the therapeutic index of cytotoxic agents. Finally, by marking normal or malignant cells with readily detectable genes, one can monitor the efficacy of therapy or study the dynamics of stem cell behavior in vivo. At present these applications are limited by the quality of vectors, but as transduction efficiencies and gene regulatory mechanisms improve, gene transfer can be expected to evolve into a major therapeutic modality in its own right.
UR - http://www.scopus.com/inward/record.url?scp=0031972554&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031972554&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-46836-0_8
DO - 10.1007/978-3-642-46836-0_8
M3 - Review article
C2 - 9304708
AN - SCOPUS:0031972554
VL - 144
SP - 60
EP - 69
JO - Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
JF - Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
SN - 0080-0015
ER -